Results 41 to 50 of about 29,323 (302)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Irreversible Electroporation [PDF]

open access: yesSeminars in Interventional Radiology, 2015
Irreversible electroporation (IRE) is a predominantly nonthermal ablative technology that uses high-voltage, low-energy DC current pulses to induce cell death. Thermal ablative technologies such as radiofrequency ablation, microwave ablation, and cryoablation have several applications in oncology but have limitations that have been established. IRE has
openaire   +2 more sources

Time-reversal invariance and irreversibility in time-asymmetric quantum mechanics [PDF]

open access: yes, 2005
The aim of this paper is to analyze the concepts of time-reversal invariance and irreversibility in the so-called 'time-asymmetric quantum mechanics'. We begin with pointing out the difference between these two concepts.
Castagnino, Mario   +5 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Analysis and Optimization of Exergy Flows inside a Transcritical CO2 Ejector for Refrigeration, Air Conditioning and Heat Pump Cycles

open access: yesEnergies, 2019
In this study, the exergy analysis of a CO2 (R744) two-phase ejector was performed using a 1D model for both single and double choking conditions. The impact of the back pressure on the exergy destruction and exergy efficiencies was presented to evaluate
Sahar Taslimi Taleghani   +2 more
doaj   +1 more source

Popper on irreversibility and the arrow of time [PDF]

open access: yes, 2005
Popper challenges the mainstream account of irreversibility, which refers to thermodynamics, by putting forward three theses: (1) There are irreversible processes of wave-production.
Esfeld, Michael
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Investigation of a Hybridized Cascade Trigeneration Cycle Combined with a District Heating and Air Conditioning System Using Vapour Absorption Refrigeration Cooling: Energy and Exergy Assessments

open access: yesEnergies
The insufficiency of energy supply and availability remains a significant global energy challenge. This work proposes a novel approach to addressing global energy challenges by testing the supercritical property and conversion of low-temperature thermal ...
Larry Orobome Agberegha   +8 more
doaj   +1 more source

Irreversibility Analysis and Numerical Simulation in a Finned-Tube Heat Exchanger Equipped with Block Shape Vortex Generator [PDF]

open access: yesInternational Journal of Advanced Design and Manufacturing Technology, 2015
In this paper the effect of block shape Vortex Generators (VGs) on an air-water fin-tube heat exchanger has been studied experimentally using exergy analysis method.
M. Ghazikhani   +2 more
doaj  

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