Results 41 to 50 of about 35,904 (298)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Energies, 2019 In this study, the exergy analysis of a CO2 (R744) two-phase ejector was performed using a 1D model for both single and double choking conditions. The impact of the back pressure on the exergy destruction and exergy efficiencies was presented to evaluate
Sahar Taslimi Taleghani +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
EnergiesThe insufficiency of energy supply and availability remains a significant global energy challenge. This work proposes a novel approach to addressing global energy challenges by testing the supercritical property and conversion of low-temperature thermal ...
Larry Orobome Agberegha +8 more
doaj +1 more source
Irreversibility Analysis and Numerical Simulation in a Finned-Tube Heat Exchanger Equipped with Block Shape Vortex Generator [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2015 In this paper the effect of block shape Vortex Generators (VGs) on an air-water fin-tube heat exchanger has been studied experimentally using exergy analysis method.
M. Ghazikhani +2 more
doaj
On Thermodynamic Interpretation of Transfer Entropy
Entropy, 2013 We propose a thermodynamic interpretation of transfer entropy near equilibrium, using a specialised Boltzmann’s principle. The approach relates conditional probabilities to the probabilities of the corresponding state transitions.
Don C. Price +2 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Popper on irreversibility and the arrow of time [PDF]
, 2005 Popper challenges the mainstream account of irreversibility, which refers to thermodynamics, by putting forward three theses: (1) There are irreversible processes of wave-production.
Esfeld, Michael
core
ParticlesDespite the huge number of studies of the three-body problem in physics and mathematics, the study of this problem remains relevant due to both its wide practical application and taking into account its fundamental importance for the theory of dynamical ...
Ashot S. Gevorkyan +2 more
doaj +1 more source