Results 141 to 150 of about 129,294 (318)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Diagnostic potential of various laboratory tests for irritable bowel syndrome (IBS): a systematic review

Journal of the Pakistan Medical Association
Objective: To identify possible tests along with their accuracies that may be used to diagnose irritable bowel syndrome. Method: The systematic review comprised literature search on Cochrane Library, PubMed, Science Direct and Elsevier databases for ...
Misha Mansoor, Muhammad Hamza Shafiq, Mahnoor Imran, Fiza Mushtaq, Sana Iftikhar, Fuad Shafiq   +5 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Placebo effect in patients with diarrhea-type irritable bowel syndrome: a literature review of randomized, placebo-controlled trials [PDF]

, 2022
Ning Dai, Qingyun He, Wen Qiao, Yifei Zhang, Shi-Bing Liang, Jiali Wei, Jingli Xing, Jianping Liu   +7 more
openalex   +1 more source

Irritable Bowel Syndrome

Annals of Internal Medicine, 1979
N G, Thompson, K W, Heaton
openaire   +2 more sources

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, EarlyView.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

Real‐world benefits and tolerability of trofinetide for the treatment of Rett syndrome: The LOTUS study

Developmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.70051 Abstract Aim To describe the real‐world effects of trofinetide in individuals with Rett syndrome (RTT) using the 18‐month follow‐up analysis of the LOTUS study. Method Caregivers of any patients who were prescribed trofinetide under routine clinical care were eligible to ...
Louise Cosand, Haya Mayman, Jenny Downs, Victor Abler   +3 more
wiley   +1 more source

Comparison of effectiveness of acceptance commitment therapy and metacognitive therapy on reducing symptoms, psychological capital and quality of life of patients suffering from irritable bowel syndrome [PDF]

, 2019
Sarah Pashing, Aniss khosh Lahjeh Sedgh
openalex   +1 more source

Beyond the spike: Functional (dissociative) seizures as a key to holistic attitudes in seizure disorders

Epilepsia, EarlyView.
Abstract Epileptologists can improve outcomes through follow‐up and coordination of care for patients with functional seizures. Epileptic and functional seizures share some mechanistic overlap involving interoceptive, emotional, and stress dysregulation, and disorders of agency and perception. Similar psychiatric and neurological comorbidities occur at
Mahinda Yogarajah, Barbara Dworetzky, Josemir W. Sander, Angel Aledo‐Serrano   +3 more
wiley   +1 more source