Results 151 to 160 of about 259,999 (280)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Irritability in Bipolar Depression: Re-Examining a Neglected Dimension. [PDF]

Bipolar Disord
Attanasio F, Fumagalli C, Miazzi R, Fazio V, Colombo C.   +4 more
europepmc   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Association between affective temperaments and thalamic nuclei volumes. [PDF]

Front Psychiatry
Hirakawa H, Kohno H, Muronaga M, Izumi T, Ogawa T, Nagano Y, Abeyama T, Kohno K.   +7 more
europepmc   +1 more source

Review: Co‐occurring psychiatric disorders and symptomatology among children and adolescents with neurodevelopmental disorders – an umbrella review with individual study meta‐analysis

Child and Adolescent Mental Health, EarlyView.
Background Neurodevelopmental disorders (NDDs), including attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), intellectual disability (ID), and specific learning disorders (SLD), frequently co‐occur with psychiatric conditions (e.g. anxiety, depression).
Kathryn Fortnum, Noah Erskine, John Cairney, Matthew Y. W. Kwan, Matthew Bourke   +4 more
wiley   +1 more source

Ambiguous Loss in the Family: Sibling Perspectives of Change and Caregiving in the Context of Mental Illness

Child &Family Social Work, EarlyView.
ABSTRACT This qualitative study examines the lived experiences of emerging adults (aged 18–29) who have siblings with mental illness (aged 12–16), with a focus on family dynamics, emotional well‐being and caregiving responsibilities. Drawing on in‐depth semi‐structured interviews with 32 participants recruited via snowball sampling and social media ...
Michal Labes, Batel Hazan‐Liran, Inbar Levkovich   +2 more
wiley   +1 more source

Reimagining the White Child as Other: Taika Waititi's Decolonial Play in James and the Giant Peach With Taika and Friends

Children &Society, EarlyView.
ABSTRACT This article examines how James and the Giant Peach with Taika and Friends (JGPTF) (2020) challenges the colonial logics embedded in Roald Dahl's construction of the universal white child. Through collaborative digital play, humour and Māori relational epistemologies, Taika Waititi unsettles James's position as the normative child of futurity,
Diana Sandars
wiley   +1 more source

Sleep profiles in individuals with rare neurogenetic syndromes

Developmental Medicine &Child Neurology, EarlyView.
Aim To characterize sleep profiles in individuals with neurogenetic disorders (NGDs) and examine the contribution of key clinical and psychiatric symptoms to these profiles. Method The parents of 248 individuals (aged 3–45 years) diagnosed with a range of NGDs, including PTEN hamartoma tumor syndrome (n = 111), SYNGAP1‐related intellectual disability ...
Isabella C. Reyes, Thomas W. Frazier, Antonio Y. Hardan, Lacey Chetcuti, Samuel J. R. A. Chawner, Emily Spackman, Mirko Uljarević, Emma K. Baker   +7 more
wiley   +1 more source

Illness Uncertainty in Pediatric Irritable Bowel Syndrome: A Pilot Study. [PDF]

Children (Basel)
Gamwell KL, Robbertz AS, Peugh JL, Santucci N, Graham K, Hommel KA.   +5 more
europepmc   +1 more source

Sleep disturbances in children with cerebral palsy, their siblings, and parents: A qualitative descriptive study

Developmental Medicine &Child Neurology, EarlyView.
Children with cerebral palsy who experienced clinically significant sleep disturbances, their parents, and their siblings, were interviewed to understand the impact of sleep disturbance on the whole family. Six themes were identified, demonstrating the need for tailored, multidisciplinary, holistic sleep assessment and intervention, and family support.
Mary‐Elaine McCavert, Oliver Perra, Karen McConnell, Claire Kerr   +3 more
wiley   +1 more source