Results 71 to 80 of about 8,971 (247)

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Updated EAACI Statement on Drug Hypersensitivity Skin Testing: Methodology and Non‐Irritative Concentrations

Allergy, EarlyView.
ABSTRACT These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase.
Annick Barbaud, Lene Heise Garvey, Elizabeth Phillips, Michael Ardern‐Jones, Sevim Bavbek, Patrizia Bonadonna, Jean‐Christoph Caubet, Ana‐Maria Copaescu, Valentina Gueli, Jose Julio Laguna, Ricardo Madrigal‐Burgaleta, Francesca Mori, Vito Sabato, Maria J Torres, Knut Brockow   +14 more
wiley   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Facial Irritant Contact Dermatitis Caused by Pyraclostrobin

Clinical, Cosmetic and Investigational Dermatology, 2022
Qiuyue Wang,1,2 Nana Luo,1,2 Min Lei,1,2 Lingyuan Zhong,1,2 Chunxiao Li,2,* Pingsheng Hao2,* 1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of Dermatology, Hospital
Wang Q, Luo N, Lei M, Zhong L, Li C, Hao P   +5 more
doaj  

Significantly Different Prevalences of Contact Allergy to Hydroperoxides of Linalool and Limonene When Patch Testing With Different Patch Test Chambers

Contact Dermatitis, EarlyView.
Finn Chamber AQUA (FCA) detects significantly higher contact allergy prevalences to linalool hydroperoxides (7.0% vs. 5.1% FC) and limonene hydroperoxides (7.8% vs. 3.0% FC, 3.8% IQ) than Finn Chamber (FC) or IQ Ultra (IQ) in 629 dermatitis patients; chamber choice is therefore crucial for diagnostics.
Henrik Luu, Thanisorn Sukakul, Magnus Bruze, Martin Mowitz, Cecilia Svedman   +4 more
wiley   +1 more source

High Frequency of Sensitisation to Decyl and Lauryl Glucoside in Routine Patch Testing in the Netherland

Contact Dermatitis, EarlyView.
Routine testing with alkyl glucosides at Amsterdam UMC between 2019 and 2026 in a cohort of 4343 patients revealed frequent reactions to decyl glucoside (3.5%), lauryl glucoside (3.1%) or to one or both of these (5.2%). A substantial proportion of doubtful reactions and the virtual absence of strongly positive reactions suggest that the glucoside patch
Norbertus A. Ipenburg, Anton C. de Groot, Thomas Rustemeyer   +2 more
wiley   +1 more source

Benzalkonium Chloride in Eye Drops Causing Allergic Contact Dermatitis: A Case Series. [PDF]

Australas J Dermatol
ABSTRACT We present three patients who developed allergic contact dermatitis (ACD) from benzalkonium chloride (BAK) in ophthalmic drops. BAK is a preservative commonly found in ophthalmic formulations and there is a rising trend of ACD to this allergen. The irritant and sensitising properties of BAK on the ocular mucosa will be discussed.
Kannen A, Harrison P, Christou E.
europepmc   +2 more sources

Gold Contact Sensitization, Clinical Characteristics and Associations With Autoimmune Disease: A Retrospective Cohort Study With Registry Linkage

Contact Dermatitis, EarlyView.
In 3436 consecutively patch‐tested dermatitis patients, gold sensitization was common and increasingly overlapped with other metal allergies, particularly nickel. However, gold sensitization was not associated with autoimmune disease, suggesting that its clinical significance lies more in co‐sensitization than systemic autoimmunity.
Mikkel Bak Jensen, Malin Glindvad Ahström, Jannat Ahmad, Nikolai Loft, Charlotte G. Mortz, Jeanne Duus Johansen   +5 more
wiley   +1 more source