Results 191 to 200 of about 256,019 (299)

Development and evaluation of madecassoside-loaded microemulsion for enhanced topical drug delivery. [PDF]

Int J Pharm X
Chiu IH, Vu QL, Wu PC.
europepmc   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

All-Suture Fixation for Acute Turf Toe Injuries. [PDF]

JBJS Essent Surg Tech
Pappa NK, Haritos C, Ardavanis KS, Eckel T, Martin KD.   +4 more
europepmc   +1 more source

Nanocatalytic Immunotherapy Targeting Tumor‐Resident Intracellular Bacteria for Triple‐Negative Breast Cancer Treatment and Metastasis Suppression

Advanced Science, EarlyView.
Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng, Tao Jiang, Zhao Guo, Zhimin Zhang, Yihan Chen, Pan Li, Min Ge, Han Lin, Liang Zhang   +8 more
wiley   +1 more source

Crisaborole-Loaded Nanoemulsion for Atopic Dermatitis: Localized Dermal Delivery of a Phosphodiesterase-4 Inhibitor. [PDF]

Pharmaceutics
Espinoza LC, Sosa L, Sarango-Granda P, Sánchez-López E, Rosales-Sánchez J, Gualotuña Campoverde D, Polo R, Mallandrich M, Calpena AC.   +8 more
europepmc   +1 more source

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

Dual Suppression of Oxidative Stress and JAK/STAT3 Signaling Attenuates Inflammation‐Driven Corneal Neovascularization

Advanced Science, EarlyView.
Corneal neovascularization is sustained by oxidative stress and inflammatory STAT3 signaling. A macrophage membrane‐cloaked nanozyme, Sta@MSR, combines ruthenium‐mediated ROS scavenging with Stattic‐mediated STAT3 inhibition. Delivered as eye drops, Sta@MSR enhances ocular retention and corneal penetration, reduces inflammatory and angiogenic responses,
Qinghua Li, Ruoxi Li, Bingxin Ren, Chaoya Gong, Hui Yan, Jie Chen, Benzhao Fu, Chaoqun Wei, Qingdong Bao, Yang Li, Xiaoxue Liu, Wenlong Li, Hua Gao   +12 more
wiley   +1 more source

Current and emerging new approach & methodologies for skin hazard assessment. [PDF]

Toxicol Res
Shin SY, Lim KM.
europepmc   +1 more source

ALDH2 Deficiency Promotes Mitochondrial Oxidative Stress and Adverse Limb Outcomes via VDAC–HSP60 Signaling

Advanced Science, EarlyView.
ALDH2 deficiency promotes 4‐HNE accumulation, resulting in covalent modification of HSP60, disruption of its oligomeric assembly, and VDAC1‐dependent release of HSP60 from mitochondria to the cytosol. Pharmacological activation of ALDH2 preserves HSP60 proteostasis and mitochondrial integrity, whereas the clinical association between the ALDH2 rs671 ...
You‐Cheng Lin, Nan‐Chun Wu, Chon‐Seng Hong, Po‐Chao Hsu, Wen‐Jin Yang, Yi‐Cheng Chang, Che‐Hong Chen, Wei‐Ting Chang   +7 more
wiley   +1 more source

A TRPA1-mediated substance P release assay as an <i>in vitro</i> screening tool for airway irritant potential. [PDF]

Front Toxicol
Bedford R, Medhane R, Lawrance J, Hollings M.   +3 more
europepmc   +1 more source