Results 121 to 130 of about 108,365 (300)
Advanced Science, EarlyView.ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu +10 more
wiley +1 more source
Advanced Science, EarlyView.Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao +19 more
wiley +1 more source
ZrCo3B2 and HfCo3B2 Electrodes Go on Stage for Oxygen Evolution Reaction
Advanced Science, EarlyView.The intermetallic compounds ZrCo3B2 and HfCo3B2 with distinctive chemical bonding features are excellent OER precursors, restructuring into OER‐active electrocatalysts delivering significantly high OER activities compared to the elemental Co, which is obvious from their lower onset potentials and increased obtained current densities.
Fatma Aras +4 more
wiley +1 more source
Advanced Science, EarlyView.AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan +13 more
wiley +1 more source
Ir nereikalingas, ir bereikalingas
, 2001 Straipsnyje analizuojamos žodžių 'bereikalingas' ir 'nereikalingas' reikšmės. Netipiškos darybos tarmių ir raštų žodis 'bereikalingas' J. Jablonskio pažintas iš gimtosios tarmės, jo užrašytas žodynui, svetimu nelaikytas, griežtai netaisytas. Žodžio 'bereikalingas' lietuvišką atsiradimą labai įtikinamai paaiškino A.Salys. Jį pateisino „Kalbos patarėjas“.
openaire +1 more source
Advanced Science, EarlyView.This work demonstrates the implementation of MOF‐assisted anode and cathode materials for prolonged cycling of zinc‐air batteries with strong redox capability and structural stability. ABSTRACT The surface modification of zinc anodes and the development of effective cathode dual‐functional oxygen electrocatalysts remain of paramount interest for ...
Ramasamy Santhosh Kumar +7 more
wiley +1 more source
IRS Modernization: IRS Should Enhance Its Performance Management System [PDF]
, 2001 A letter report issued by the General Accounting Office with an abstract that begins "The Internal Revenue Service (IRS) has made progress in revamping its performance management system.
United States. General Accounting Office.
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Mixed‐Valence Atomic‐Layer Iridium Patches Enhance Alkaline Hydrogen Evolution
Advanced Science, EarlyView.Engineering iridium architectures on Cu3P nanowires reveals that atomic‐layer Ir patches form a mixed‐valence interfacial motif with an anisotropic electronic structure. This configuration balances water dissociation and hydrogen adsorption/desorption, delivering superior alkaline hydrogen evolution with a 27 mV overpotential and 1 A cm−2 operation in ...
Payam Ahmadian Koudakan +7 more
wiley +1 more source
Il mercato dei derivati over-the-counter
, 1995 Descrizione del mercato dei derivati over-the-counter e dei meccanismi di determinazione del ...
ROSSI, EDUARDO
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Advanced Science, EarlyView.DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang +8 more
wiley +1 more source