Results 101 to 110 of about 108,365 (300)

CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1

Cell Reports, 2019
Summary: The tumor suppressor CYLD is a deubiquitinating enzyme that removes non-degradative ubiquitin linkages bound to a variety of signal transduction adaptors.
Tiphaine Douanne, Gwennan André-Grégoire, An Thys, Kilian Trillet, Julie Gavard, Nicolas Bidère   +5 more
doaj   +1 more source

Chlorine‐Functionalized Silane‐Modified Copper Electrocatalyst for Enhanced CO2 Reduction to Multi‐Carbon Products

Advanced Science, EarlyView.
A chlorine‐functionalized silane modifier (CPTMS) is introduced to cooperatively regulate CO2 reduction to C2+ products on Cu‐based catalysts. Dual‐functional interface sequentially enhances CO2 activation, intermediates protonation and C─C coupling, delivering a 5‐fold increase in C2+ faradaic efficiency (FE, 75% vs.
Ying Ying Ch'ng, Sankhadip Saha, Ming Zhang, Shujie Zhou, Lixue Jiang, Putri Ramadhany, Jitraporn Vongsvivut, Adrian Cernescu, Priyank Vijaya Kumar, Yihao Shan, Zhipeng Ma, Xiaoxuan Luo, Rahman Daiyan, Zhaojun Han, Rose Amal   +14 more
wiley   +1 more source

Spatial Fit, from Panacea to Practice: Implementing the EU Water Framework Directive

Ecology and Society, 2012
Within the broad discourse on the concept of fit and its relevance for the governance of social-ecological systems, problems of spatial fit have attracted particular attention.
Timothy Moss
doaj   +1 more source

Visible‐Light‐Mediated Lewis Acid‐Catalyzed Diradical Hydrogen Atom Transfer Reaction of Enamides

Advanced Science, EarlyView.
The Lewis acid catalysis was crucial for the success of the DHAT reaction of enamides by lowering the energy of the triplet excited state and modulating the reactivity of the formed diradical intermediate in a carbon‐to‐carbon 1,5‐DHAT and consequent cyclization that allows the functionalization of C(sp3)−H bonds to construct a variety of novel β ...
Yao Huang, Baoyu Yang, Xiang Zhou, Israel Fernández, Kexue Xia, Yang Xiong   +5 more
wiley   +1 more source

Arbeitsprogramm 1997/98 (Institut fuer Regionalentwicklung und Strukturplanung -IRS-)

, 1997
'Nach den Jahren des Aufbaus (Gruendung am 1.1.1992 auf Empfehlung des Wissenschaftsrates als Institut der Blauen Liste) hat das Institut fuer Regionalentwicklung und Strukturplanung (IRS) seit 1995 begonnen, in ausgewaehlten Forschungsschwerpunkten die ...
Institut fuer Regionalentwicklung und Strukturplanung -IRS-, Erkner (Germany)
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Toward High‐Resolution Polymeric Neural Interfaces: A Practical Guide for Electron Beam Lithography

Advanced Science, EarlyView.
Electron beam lithography (EBL) enables sub‐micron patterning of polymer‐based neural implants, overcoming the resolution limits of optical lithography. By addressing challenges such as charging, non‐planarity, and substrate heating, it supports higher channel density, improved miniaturization, and better long‐term tissue integration.
Hanna Karlsson‐Fernberg, Maria Asplund
wiley   +1 more source

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Jahresbericht 1999/ 2000 / IRS Institut fuer Regionalentwicklung und Strukturplanung

, 2001
In diesem Jahresbericht werden die Arbeiten und Ergebnisse des IRS fuer die Jahre 1999 und 2000 vorgestellt. Die unterschiedlichen, aber aufeinander bezogenen Projektthemen sind im Wesentlichen den folgenden sechs Forschungsschwerpunkten zugeordnet ...
Institut fuer Regionalentwicklung und Strukturplanung -IRS-, Erkner (Germany)
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Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Arbeitsprogramm 1997/98 (Institut fuer Regionalentwicklung und Strukturplanung -IRS-)

, 1999
'Mit diesem Arbeitsprogramm beginnt das Institut einige neue Forschungsthemen, ohne dabei aber die Kontinuitaet des Forschungsprofils, wirtschaftsraeumliche, ressourcenoekologische und soziokulturelle Anforderungen an raeumliche Entwicklungen in den ...
Institut fuer Regionalentwicklung und Strukturplanung -IRS-, Erkner (Germany)
core