Results 221 to 230 of about 965,659 (315)

A New Model of Bilateral Hemispheric Ischemia in the Unanesthetized Rat

Stroke, 1979
W. Pulsinelli, J. Brierley
semanticscholar   +1 more source

Microglia Drive Peripapillary Vascular Density Reduction in Normal Tension Glaucoma by Regulating the Rpl17/Stat5b/Apoa1 Axis

Advanced Science, EarlyView.
This study revealed that E50K mutant microglia drive retinal peripapillary vascular density reduction in NTG via the Rpl17/Stat5b/Apoa1 axis and identified Apoa1 as a novel suppressor of retinal vascular endothelial cells. These findings identify a potential therapeutic target for glaucoma and support the clinical potential of EA for protecting RGCs ...
Di Zhang, Sisi Chen, Yanfeng Zhang, Leyi Qiu, Mengxian Du, Wulian Song, Fengyi Guo, Jingyang Zhang, Xinna Liu, Huiping Yuan   +9 more
wiley   +1 more source

Targeted neuroprotection with OX26-functionalized Epigallocatechin-3-gallate (EGCG)-stabilized se nanoparticles in a rat model of cerebral ischemia. [PDF]

Sci Rep
Akcay G, Celik C, Yildiz G, Balcioglu E, Baydemir R, Altunay S, Ocsoy I.   +6 more
europepmc   +1 more source

Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation

Advanced Science, EarlyView.
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu, Hongtao Song, Limin He, Zhihao Hu, Yu Li, Chao Xu, Shaojie Liu, Jun Jiang, Yike Zhou, Zhengxuan Li, Zeyu Li, Keying Zhang, Shuaijun Ma, Ruochen Qi, Shichao Han, Changhong Shi, Weihong Wen, Donghui Han, Weijun Qin   +18 more
wiley   +1 more source

Hemin-induced HO-1 protects isolated rat hearts from ischemia-reperfusion injury by activation of pro-survival signalling pathways. [PDF]

Am J Transl Res
Koria H, Mehta A.
europepmc   +1 more source

Myocardial Edema After Ischemia/Reperfusion Is Not Stable and Follows a Bimodal Pattern

, 2014
Rodrigo Fernández‐Jiménez, Javier Sánchez‐González, Jaume Agüero, Jaime García‐Prieto, Gonzalo J. López-Martín, José M. García‐Ruiz, Antonio Molina, Xavier Rosselló, Leticia Fernández‐Friera, Gonzalo Pizarro, Ana García‐Álvarez, Erica Dall’Armellina, Carlos Macaya, Robin P. Choudhury, Valentı́n Fuster, Borja Ibáñez   +15 more
openalex   +1 more source

Mechanisms of lung ischemia-reperfusion injury

Current Opinion in Organ Transplantation, 2016
V. Laubach, Ashish K Sharma
semanticscholar   +1 more source

Multiscale Construction, Evaluation, and Application of Organoids

Advanced Science, EarlyView.
Organoids are pivotal models with transformative biomedical potential. A comprehensive multi‐scale perspective is presented, encompassing dual‐scale construction, four‐dimensional evaluation, triple‐point application, and an analysis of the current challenges faced by organoid technology, aiming to advance organoid research and its biomedical ...
Wanting Ma, Zhenglin Dong, Zhu'anzhen Zheng, Long Bai, Xingcai Zhang, Jiacan Su   +5 more
wiley   +1 more source

Interval Skin Necrosis in the Infrapopliteal Segment after Successful Distal Bypass Grafting in a Patient with Chronic Limb-Threatening Ischemia Complicated by Rheumatoid Arthritis Receiving Long-Term Corticosteroid Therapy. [PDF]

Ann Vasc Dis
Doita T, Kikuchi S, Tamaru Y, Jinno H, Kamada K, Kuriyama N, Miyake K, Miyagawa S, Azuma N.   +8 more
europepmc   +1 more source

Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation

Advanced Science, EarlyView.
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li, Maoxiang Xu, Boyu Cai, Xiangyu Li, Zhanping Liang, Xiaohuan Xia, Haitao Zhang, Zhiwen Zhang, Fei Tan, Jialin Charlie Zheng   +9 more
wiley   +1 more source