Results 91 to 100 of about 76,994 (304)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Time to admission in acute ischemic stroke and transient ischemic attack

, 2006
BACKGROUND AND PURPOSE: The effect of thrombolysis depends on the time from stroke onset to treatment and therefore also on the time when patients come to the hospital. This study was designed to analyze the variables that influence the time from symptom
Arnold, Marcel, Agyeman, Osei, Isenegger, Joerg, Nedeltchev, Krassen, Fischer, Urs, Schroth, Gerhard, Mattle, Heinrich P, Remonda, Luca   +7 more
core   +1 more source

Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset [PDF]

, 2010
<p><b>Background and Purpose:</b> Antiplatelets (APs) may increase the risk of symptomatic intracerebral hemorrhage (ICH) following intravenous thrombolysis after ischemic stroke.</p> <p><b>Methods:</b> We ...
Wahlgren, N., Luijckx, G-J, Sykora, M., Wahlgren, N,, Diedler, J., Diedler, Jennifer, Overgaard, Karsten, Overgaard, K., Diedler, J, Ringleb, Peter, Uyttenboogaart, M., Ford, G.A., Soinne, Lauri, Overgaard, K, Lees, K.R., Lees, KR, Sykora, M, Uyttenboogaart, M, Uyttenboogaart, Maarten, Ringleb, P., Ahmed, Niaz, Luijckx, G.J., Luijckx, Gert-Jan, Ahmed, N,, Ahmed, N., Lees, Kennedy R., Wahlgren, Nils, Ford, GA, Soinne, L, Soinne, L., Sykora, Marek, Ford, Gary A., Uyttenboogaart, Maarten; id_orcid   +32 more
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Long-term outcome following attendance at a transient ischemic attack clinic

, 2011
Background and purpose Many patients who attend transient ischemic attack clinics have a noncerebrovascular diagnosis. The long-term outcomes in this group are not well described.
Walters, M.R., Gordon T. McInnes, William Sloan, Dawson, J., Sloan, W., Cameron, A., Jesse Dawson, Terence J. Quinn, Lees, K.R., McInnes, G.T., Morrison, D., Kennedy R. Lees, Alan C. Cameron, M.R. Walters, Quinn, T.J., David Morrison   +15 more
core   +1 more source

Ischemic Benefit and Hemorrhage Risk of Ticagrelor-Aspirin Versus Aspirin in Patients With Acute Ischemic Stroke or Transient Ischemic Attack

, 2021
Background and Purpose: In patients with acute mild-moderate ischemic stroke or high-risk transient ischemic attack, the THALES trial (Acute Stroke or Transient Ischemic Attack Treated With Ticagrelor and Aspirin for Prevention of Stroke and Death ...
Sven Nylander, Stefan James, Amarenco, Pierre, Roether, Joachim,, Evans, Scott R., Joachim Röther, Aunes, Maria,, Anders Himmelmann, Amarenco, Pierre,, Jahreskog, Marianne,, Himmelmann, Anders,, James, Stefan, Ladenvall, Per, Yongjun Wang, Denison, Hans, Himmelmann, Anders, Ladenvall, Per,, Mikael Knutsson, S. Claiborne Johnston, Scott R. Evans, Nylander, Sven,, Molina, Carlos A.,, Per Ladenvall, Denison, Hans,, Knutsson, Mikael,, Nylander, Sven, Johnston, S. Claiborne, Hans Denison, Maria Aunes, Knutsson, Mikael, Johnston, S. Claiborne,, Roether, Joachim, Aunes, Maria, Wang, Yongjun,, Marianne Jahreskog, Evans, Scott R.,, Jahreskog, Marianne, James, Stefan,, Carlos A. Molina, Molina, Carlos A., Pierre Amarenco, Wang, Yongjun   +41 more
core   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Ataque transitorio de isquemia, el heraldo del ictus Transient ischemic attack: the herald of stroke

Revista Cubana de Investigaciones Biomédicas, 2012
Introducción: el ataque transitorio de isquemia constituye una parte fundamental de la enfermedad cerebrovascular, en muchas ocasiones no bien diagnosticado por su corta duración, lo difícil de ver y sus variadas manifestaciones clínicas.
Javier Sánchez López, Isis Rodríguez Ribalta, Martha Beatriz Díaz Dehesa   +2 more
doaj  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Risk Factors Associated with Recurrent Strokes in Young and Elderly Patients: A Hospital-based Study

International Journal of Gerontology, 2015
Background: Recurrent stroke is often devastating, and can cause severe disability or death. Risk factors associated with recurrent strokes unrelated to atrial fibrillation have been well identified; however, it remains to be further elucidated whether ...
Guang-Rong Fu, Wei-Qiang Yuan, Wan-Liang Du, Zhong-Hua Yang, Na Fu, Hua-Guang Zheng, Zi-Xiao Li, Yu-Ming Huang, Yu-Mmei Zhang, Guang-Zheng Dai, Hua-Bing Wang, Jian-Mei Li, Jing-Dong Yi, Qing-Biao Yang, Hong-Jun Tian, Li-Nan He, Geng-Yu Li, Jia-Li Zhang, Li-Mei Yang, Yan Gao, Zi-Wei Fu   +20 more
doaj   +1 more source