Results 121 to 130 of about 1,279,230 (303)

Baseline characteristics of patients with acute ischemic stroke/transient ischemic attack.

, 2016
Baseline characteristics of patients with acute ischemic stroke/transient ischemic attack.
Christoph Kleinschnitz (93826), Peter Kraft (15118), Christiane Drechsler (412846), Ignaz Gunreben (579574), Peter Ulrich Heuschmann (462698)   +4 more
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Detection of Varicella Zoster Virus Reactivation in Cerebrospinal Fluid in Ischemic Stroke or Transient Ischemic Attack

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Epidemiological data suggest that the risk of ischemic stroke increases after varicella‐zoster virus (VZV) reactivation. The frequency of VZV reactivation in acute ischemic stroke (AIS) is unknown.
Wenyang Li, Peter Sguigna, Chintan Rupareliya, Suriya Subramanian, Hisham Salahuddin, Khalil S. Husari, William Moore, Mark Johnson, Alejandro Magadan, Charles Grose, Ank E. Nijhawan, Ty Shang   +11 more
doaj   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Intravenous thrombolysis for acute ischemic stroke occurring during hospitalization for transient ischemic attack

, 2014
Background: There are limited data regarding the use of intravenous thrombolysis in patients who experienced acute ischemic symptoms during their hospitalization for prior transient ischemic attack. Aim: We sought to prospectively evaluate the safety and
Bavarsad Shahripour, R., Tsivgoulis, G., Sharma, V.K., Haršány, M., Alexandrov, A.V., Athanasiadis, D., Mikulik, R., Teoh, H.L., Krogias, C., Piperidou, C.   +9 more
core   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Editorial: Transient ischemic attack: standard-of-care model

Frontiers in Neurology, 2023
Narayanaswamy Venketasubramanian, Thanh G. Phan, Thanh G. Phan, Jiang Li, John Van Ly, John Van Ly, Saeideh Aghayari Sheikh Neshin   +6 more
doaj   +1 more source

Transient Ischemic Attacks [PDF]

Stroke, 2006
Rothwell, P, Johnston, S
openaire   +2 more sources