Results 201 to 210 of about 211,243 (308)

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

Comparing the risk of subsequent ischemic stroke and mortality in patients with epilepsy and patients with ischemic stroke. [PDF]

Epilepsy Behav Rep
Lin PY, Lin SH, Sung PS.
europepmc   +1 more source

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

Exploration, EarlyView.
We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley   +1 more source

Dual antiplatelet therapy versus aspirin alone in acute ischemic stroke or transient ischemic attack: A meta-analysis and trial sequential analysis of randomized controlled trials. [PDF]

J Int Med Res
Odat RM, Alshwayyat S, Bahdar ZI, Abdelraheem M, Khalefa BB, Jarah O, Obeidat MH, Bani Khalaf ME, Bani Khalaf AJ, Hussein AM, Yasin JA, Hanifa H, Jain H.   +12 more
europepmc   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Provision of information, secondary stroke prevention and holistic care for post-transient ischemic attack patients: A scoping review. [PDF]

Medicine (Baltimore)
Ho WS, Mohd Nordin NA, Abdul Aziz AF.
europepmc   +1 more source

Glial Versus Neuronal Na+/K+‐ATPase in Activity‐Evoked K+ Clearance and Their Sensitivity to Elevated Extracellular K+

Glia, EarlyView.
The glial Na+ pump regulates [K+]o during neuronal activity, and the neuronal version restores [K+]o to baseline. Spreading depression‐related rise of K+ does not cause SD propagation via suppression of Na+/K+‐ATPase or glutamate transport. ABSTRACT Neuronal activity in the central nervous system is associated with a [K+]o transient that is swiftly ...
Brian Skriver Nielsen, Brian Roland Larsen, Afnan Bilal Ghazal, Adriana Katz, K. C. Brennan, Steven J. D. Karlish, Nanna MacAulay   +6 more
wiley   +1 more source

Prevalence of Stroke and Associated Risk Factors in Patients With Atrial Fibrillation: A Cross-Sectional Study. [PDF]

Cureus
Gul N, Habib S, Tayong FM, Ali A, K J J, Khan N, Asghar P, Khayam, Faisal S, Shahjehan S.   +9 more
europepmc   +1 more source

What Does Iron Mean to an Oligodendrocyte?

Glia, EarlyView.
ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions. The brain has the highest rate of energy consumption, and within the brain, oligodendrocytes have the highest level of oxidative metabolism per volume. Oligodendrocytes also stain the strongest for iron.
Quinn W. Wade, James R. Connor
wiley   +1 more source

Predictive value of magnetic resonance angiography combined with serum ischemia-modified albumin for secondary cerebral infarction after transient ischemic attack. [PDF]

Thromb J
Liu L, Yan Q, Ai J, Jiao R, Li M.
europepmc   +1 more source