Results 191 to 200 of about 106,174 (376)

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

open access: yesMedicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman   +6 more
wiley   +1 more source

Failure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome

open access: bronze, 1999
Habib Samady   +5 more
openalex   +1 more source

Association between NT‐proBNP changes and clinical outcomes in paediatric patients with heart failure: Insights from PANORAMA‐HF and PARADIGM‐HF

open access: yesESC Heart Failure, EarlyView.
This post hoc analysis of the PANORAMA‐HF paediatric heart failure trial evaluates the correlation of baseline and clinical changes in NT‐proBNP and clinical outcomes in children with heart failure due to left ventricular systolic dysfunction. This is the first prospective, randomized large‐scale study to demonstrate that changes in NT‐proBNP levels ...
Robert Shaddy   +17 more
wiley   +1 more source

Frataxin deficiency alters gene expression in Friedreich ataxia derived IPSC‐neurons and cardiomyocytes

open access: yesMolecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
FA is a progressive neurodegenerative disorder, but the primary cause of death is heart disease which occurs in 60% of the patients. Several functions of frataxin have been proposed, but none of them fully explain why its deficiency causes the FA phenotypes nor why the most affected cell types are neurons and cardiomyocytes.
Mariana B. Angulo   +6 more
wiley   +1 more source

Transformer-Based Self-Supervised Learning for Histopathological Classification of Ischemic Stroke Clot Origin [PDF]

open access: yesarXiv
Background and Purpose: Identifying the thromboembolism source in ischemic stroke is crucial for treatment and secondary prevention yet is often undetermined. This study describes a self-supervised deep learning approach in digital pathology of emboli for classifying ischemic stroke clot origin from histopathological images.
arxiv  

The importance of the left ventricular pacing site on the effect of biventricular pacing for heart failure in ischemic and non-ischemic dilated cardiomyopathy [PDF]

open access: bronze, 2001
Peter Mortensen   +5 more
openalex   +1 more source

Deep Learning-Driven Segmentation of Ischemic Stroke Lesions Using Multi-Channel MRI [PDF]

open access: yesarXiv
Ischemic stroke, caused by cerebral vessel occlusion, presents substantial challenges in medical imaging due to the variability and subtlety of stroke lesions. Magnetic Resonance Imaging (MRI) plays a crucial role in diagnosing and managing ischemic stroke, yet existing segmentation techniques often fail to accurately delineate lesions.
arxiv  

Obesity treatment initiation, retention, and outcomes in the Veterans Affairs MOVE! Program among rural and urban veterans

open access: yesObesity Science &Practice, Volume 8, Issue 6, Page 784-793, December 2022., 2022
Abstract Objective Rural veterans have high obesity rates. Yet, little is known about this population's engagement with the Veterans Affairs (VA) weight management program (MOVE!). The study objective is to determine whether MOVE! enrollment, anti‐obesity medication use, bariatric surgery use, retention, and outcomes differ by rurality for veterans ...
Kathleen M. Robinson   +6 more
wiley   +1 more source

The level of the cardiac peptide NT-proBNP and indices of the scale of assessment of clinical status in chronic heart failure patients with ischemic cardiomyopathy

open access: yesКубанский научный медицинский вестник, 2016
This study focuses on the comparison of the level of NT-proBNP with indicators of the scale of assessment of clinical status in chronic heart failure patients with ischemic cardiomyopathy and identify possible correlations with the severity of symptoms ...
E. I. Myasoedova   +4 more
doaj  

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