Results 261 to 270 of about 50,311 (298)
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Cardioprotection by Ischemic Preconditioning
1998Murry et al. reduced infarct size in dogs through repetitive brief occlusions, preceding prolonged ischemia, and coined this phenomenon “ischemic preconditioning.”13 ATP breakdown was attenuated during the prolonged period of ischemia, possibly due to a decrease in contractile function prior to this ischemic period.
Jonge, R +2 more
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Erythropoietin mimics ischemic preconditioning
Vascular Pharmacology, 2005Ischemic preconditioning is a powerful endogenous phenomenon in which brief periods of a sub-toxic ischemic insult induce robust protection against future, lengthy, lethal ischemia. The cardioprotective effects of ischemic preconditioning are manifest in all species studied so far, including humans. The ability to reproduce the cardioprotective effects
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Ischemic preconditioning: Exploring the paradox
Progress in Cardiovascular Diseases, 1998Brief transient episodes of nonlethal myocardial ischemia protect or "precondition" the heart and render the myocardium resistant to a subsequent more sustained ischemic insult. The hallmark of this phenomenon--documented in virtually all species and experimental models evaluated to date in countless laboratories worldwide--is the profound reduction in
K, Przyklenk, R A, Kloner
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Neuronal plasticity after ischemic preconditioning and TIA-like preconditioning ischemic periods
Acta Neuropathologica, 2008Transient ischemic attacks (TIAs) have recently become the center of attention since they are thought to share some characteristics with experimental ischemic preconditioning (IPC). This phenomenon describes the situation that a brief, per se harmless, cerebral ischemic period renders the brain resistant to a subsequent severe and normally damaging ...
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Ischemic preconditioning—an unfulfilled promise
Cardiovascular Revascularization Medicine, 2015Myocardial reperfusion injury has been identified as a key determinant of myocardial infarct size in patients undergoing percutaneous or surgical interventions. Although the molecular mechanisms underpinning reperfusion injury have been elucidated, attempts at translating this understanding into clinical benefit for patients undergoing cardiac ...
Williams, Timothy M. +4 more
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Signal Transduction in Ischemic Preconditioning
1997Ischemic preconditioning is a phenomenon in which exposure of the heart to a brief period of ischemia causes it to quickly adapt itself to become resistant to infarction from a subsequent ischemic insult. The mechanism is not fully understood but, at least in the rabbit, it is known to be triggered by occupation of adenosine receptors, opioid receptors,
J M, Downey, M V, Cohen
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[Remote ischemic preconditioning].
Uspekhi fiziologicheskikh nauk, 2010It has been systematized modern data on the preconditioning at a distance and a tolerance of a heart, a brain and other organs to ischemia-reperfusion injury. It has been performed an analysis of the published works on the role of autonomic nervous system and humoral factors in the development of resistance to pathogenic action of ischemia and ...
L N, Maslov, F, Kolar, T, Krieg
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