Results 121 to 130 of about 924,610 (305)

Significant Association Between Low Mitochondrial DNA Content in Peripheral Blood Leukocytes and Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundCumulative evidence has shown that low mitochondrial DNA (mtDNA) content is related to elevated oxidative stress and atherosclerosis, which play important roles in ischemic stroke.
Li‐Ming Lien, Hung‐Yi Chiou, Hsu‐Ling Yeh, Shang‐Yen Chiu, Jiann‐Shing Jeng, Huey‐Juan Lin, Chaur‐Jong Hu, Fang‐I Hsieh, Yau‐Huei Wei   +8 more
doaj   +1 more source

Validity of the SS-QOL in Germany and in Survivors of Hemorrhagic or Ischemic Stroke [PDF]

, 2007
Objective: The Stroke-Specific Quality of Life Scale (SS-QOL) is a recently developed measure to assess health-related quality of life in stroke patients.
Stucki, Gerold, Ewert, Thomas
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Serum ferritin is associated with the presence of ischemic stroke among individuals with type 2 diabetes

Heliyon
Background: Epidemiological evidence regarding the possible link between serum ferritin (SF) level and ischemic stroke risk among individuals with type 2 diabetes mellitus (T2DM) is sparse.
Youyou Zhang, Hui Wang, Ruirui Jia, Dong Chen, Zhaoyang Li   +4 more
doaj   +1 more source

Increased Expression of Cell-Cell Signaling Genes by Stimulated Mononuclear Leukocytes in Patients with Previous Atherothrombotic Stroke A Whole Genome Expression Profile Study [PDF]

, 2009
Background/Aims: Inflammation plays an important role in atherosclerosis and stroke. Acute infections are recognized as trigger factors for ischemic stroke. Methods: In this whole genome expression profile study of 15 patients and 15 control subjects, we
Wiest, Tina, Horstmann, Solveig, Honold, Cornelius, Hergenhahn, Manfred, Mansmann, Ulrich, Wagner, Simone, Weninger, Annette, Pfleger, Karin, Grond-Ginsbach, Caspar, Hollstein, Monika, Grau, Armin J., Hummel, Manuela, Knyazev, Yuri   +12 more
core   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Role of SH levels and markers of immune response in the stroke [PDF]

, 2013
Background. Sulfhydryl groups (SH) are considered a key factor in redox sensitive reaction of plasma, and their modification could be considered an expression of abnormal generation of oxygen free radicals. Methods. Fifty consecutive patients with acute
Arru, Giannina, Gervasoni Jacopo, D’Addessi A, Minucci, Angelo, Fois, Maria Laura, Sotgiu, Stefano, Schiattarella Arcangelo, Cocci A, Angeletti, Silvia, Schiattarella, Arcangelo, Musumeci, Maria, Gambaro Giovanni, Persichilli S, Fois ML, Persichilli, Silvia, Musumeci, Salvatore, Primiano, Aniello, Ferraro Pm, Minucci A, Musumeci M, Angeletti S, Gambaro, Giovanni, Gervasoni, Jacopo, Ferraro, Pietro Manuel, Persichilli Silvia, Musumeci S., Primiano Aniello   +26 more
core   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

The Development of Rheumatoid Arthritis–Specific Ambulatory Care–Sensitive Conditions: Results of a Consensus Process

Arthritis Care &Research, EarlyView.
Objective Ambulatory care–sensitive conditions (ACSCs) serve as indicators of access, quality, and performance of the health system. This study aimed to determine rheumatoid arthritis (RA)‐specific ACSCs for use in the evaluation of care system access and quality.
Kara Irwin, Candace H. Feldman, Claire E. H. Barber, Gabriel Fabreau, Jake Jennings, Scott Patten, Cheryl Barnabe, Inflammatory Arthritis‐Specific ACSC Consensus Process Working Group   +7 more
wiley   +1 more source

Association of winter exposure with ischemic stroke risk in nonvalvular atrial fibrillation within a CHADS₂-based risk framework: a nationwide Japanese administrative claims database study

The Egyptian Heart Journal
Background Ischemic stroke, including transient ischemic attack, exhibits seasonal variation, and the association between winter exposure and ischemic stroke risk in patients with nonvalvular atrial fibrillation (NVAF) has not been fully characterized at
Ryusuke Sakuma, Shuko Nojiri, Takuya Uematsu, Masashi Nagao, Muneaki Ishijima, Yuji Nishizaki   +5 more
doaj   +1 more source