Results 121 to 130 of about 404,120 (314)
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand +5 morewiley +1 more sourceGenetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies [PDF]
, 2012 <p>Background - Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less.Furie, K., Benn, M. (Marianne), Carty, C., Reiner, AP, Palmer, Colin N.A., Markus, Hugh S, Lindgren, Arne,, Fornage, Myriam, Algra, Ale, Nalls, Mike A, de Bakker, P.I.W., Rothwell, Peter M., Worrall, Bradford B, Nalls, Mike A., Kuhlenbaeumer, Gregor, Deary, Ian, Levi, C., Palmer, Colin N. A., Delavaran, Hossein,, Berger, K., Reiner, A.P., Sharma, P, The Australian Stroke Genetics Collaborative, including Jonathan Golledge, Higgins, P., Palmer, CN, Worrall, BB, Vicente, A.M. (Astrid M), Helgadottir, A, Thorleifsson, G. (Gudmar), Rothwell, Peter M, Kuhlenbäumer, G., Pandolfo, M, Khan, M.I. (Muhammad), Khan, M.S., Stefansson, K, Wiggins, Kerri L., Lindgren, Arne, Vicente, Astrid M., Hofman, A., Bis, JC, Kittner, Steven J., Kittner, Steven, Boncoraglio, G. (Giorgio Battista), Schmidt, Reinhold, Palmer, C.N.A. (Colin), Nordestgaard, Børge G., Paré, Guillaume, Wiggins, K.L. (Kerri), Delavaran, H, de Bakker, Paul I. W., Cheng, Y.-C. (Yu-Ching), Sale, P. (Patrizio), Cheng, YC, Wiggins, K.L., Meschia, JF, Pandolfo, M. (Massimo), Levi, C, Sudlow, C. (Cathie), Saleheen, D, ?, ?, Ringelstein, E.B., Fomage, Myriam, Bevan, S, Wiggins, KL, Gretarsdottir, S. (Solveig), Zwart, J-A. (John-Anker), Nordestgaard, B.G., Deary, I.J. (Ian), Kuhlenbäumer, G, Mosley, Thomas H, Paré, G., Nalls, M.A., Algra, A. (Ale), Hopewell, Jemma C., Oliveira, SA, Berger, K. (Klaus), Traylor, M, Seshadri, S., Boncoraglio, G.B., Valdimarsson, Einar, Wiggins, Kerri L, van Zuydam, Natalie R., Lemmens, Robin, Carty, Cara, Worrall, B.B. (Bradford B.), Fernandez-Cadenas, I. (Israel), Benn, M, Achterberg, Sefanja, Vicente, Astrid M, Thijs, V, Ikram, M Arfan, Doney, AS, Dichgans, M, Zuydam, N.R. van, Wellcome Trust Case Control Consortium 2 (WTCCC2), Norrving, Bo,, Bakker, P.I.W. (Paul) de, Furie, K.L. (Karen), Nalls, M.A. (Michael), Yadav, S, Fernandez-Cadenas, I., Longstreth, W.T., Paré, G. (Guillaume), Mitchell, BD, Bakker, P.I.W. de, Norrving, B., Holliday, Elizabeth G., van Zuydam, N.R., Achterberg, S, van Zuydam, N.R,, Traylor, Mathew, Reiner, Alex P, Sharma, Pankaj, Montaner, J., Rothwell, PM, Kee, Weang, O'Donnell, M., Carty, C. (Cara), Cheng, Yu-Ching, Carty, C, Lund University., Rothwell, P.M. (Peter), Pandolfo, Massimo, Schmidt, Helena, Int Stroke Genetics Consortium, Norrving, Bo, de Bakker, Paul I W, Davies, Gail, Chen, W-M., Gretarsdottir, S., Gschwendtner, A., Bevan, Steve, Cheng, Y.-C., Abboud, S, Sharma, P. (Pankaj), Doney, Alexander S.F.; id_orcid, Norrving, B. (Bo), Benn, M., Ferro, Jose M., Slowik, A, Walters, Matthew, Yadav, S. (Sunaina), Delavaran, H. (Hossein), Holliday, E.G., Lindgren, A. (Arne), Meschia, James F, Farrall, M. (Martin), Pera, J, Longstreth, W. T., Oliveira, Sofia A., Helgadottir, H.T. (Hafdis), Ferro, Jose M, Reiner, Alex P., Slowik, A., Ringelstein, E.Bernd, Thorsteinsdottir, U, International Stroke Genetics Consortium, Sudlow, C., Longstreth, W, Chen, W.M., Malik, R. (Rainer), Mosley, Thomas H., Markus, H.S., Thorsteinsdottir, U. (Unnur), Abboud, S., Psaty, B.M. (Bruce), Mosley, T.H., Thijs, Vincent, Ikram, Arfan, Saleheen, D., Walters, M.R. (Matthew), Traylor, M., de Bakker, P.I., Montaner, J, O'Donnell, M, Oliveira, Sofia A, Ho, W.K., Kostulas, Konstantinos, Hofman, Albert, Palmer, CNA, Levi, C. (Christopher), Chen, W.-M., Higgins, P, Bevan, S., Longstreth Jr, W.T., Doney, A.S., Mitchell, B.D. (Braxton), Seshadri, S. (Sudha), Sale, M, Ho, WK, Furie, Karen, Delavaran, H., Sale, M., Valdimarsson, E, Cheng, Y.C., Slowik, A. (Agnieszka), DeStefano, A.L. (Anita), Rosand, J. (Jonathan), Davies, G. (Gail), Helgadottir, Anna, Psaty, Bruce M., O'Donnell, M. (Martin), Australian Stroke Genetics Collaborative, Wellcome Trust Case Co, Mitchell, Braxton D., Walters, M., Doney, ASF, van Zuydam, Natalie R, de Bakker, PIW, Rosand, Jonathan, Holliday, Elizabeth G, Fernandez-Cadenas, I, Bis, Joshua C, Delavaran, Hossein, Bevan, S. (Steve), Achterberg, S. (Sefanja), Valdimarsson, E. (Einar), Lemmens, R, Bis, J.C. (Joshua), Benn, Marianne, Parati, E.A., Kubisch, C. (Christian), Gschwendtner, A. (Andreas), Hofman, Bert, Farrall, M, Montaner, J. (Joan), Meschia, J.F. (James F.), Khan, Muhammad Saleem, Kittner, Steven J, Levi, Christopher, Sudlow, Catherine; id_orcid, Davies, G, Palmer, C.N.A., Oliveira, S.A. (Sofia), Psaty, Bruce M, Rothwell, P.M., Pera, M.F. (Martin ), Parati, E.A. (Eugenio), Oliveira, S.A., Furie, K, Dichgans, M., van Zuydam, NR, Boncoraglio, Giorgio B, Kittner, S, Berger, Klaus, Pera, Joanna, Davies, G., Higgins, P. (Peter), Pandolfo, M., Holliday, EG, Valdimarsson, E., Rosand, J., Palmer, Colin N A, Ho, Weang Kee, Deary, I., Bis, J.C., Lemmens, R., Clarke, Robert, Boncoraglio, Giorgio B., Sudlow, C, Kuhlenbäumer, G. (Gregor), Schmidt, H., Abboud, Sherine, Ferro, M.T. (María), Australian Stroke Genetics Collabo, Higgins, Peter, Worrall, Bradford B., Mitchell, Braxton D, Malik, R., Boncoraglio, GB, Lindgren, A, Clarke, R., Thorsteinsdottir, Unnur, Fornage, M., Mosley, TH, Ringelstein, E Bernd, Parati, Eugenio A, DeStefano, A.L., Lemmens, R. (Robin), Stefansson, K., Markus, HS, Chen, Wei-Min, Doney, Alexander S. F., Ringelstein, EB, Bis, Joshua C., Ikram, M.A., Rosand, J, Ferro, J. M., Norrving, B, Farrall, M., Seshadri, S, International Stroke Genetics Consortium., Walters, Mathew, Kostulas, K. (Konstantinos), Thorleifsson, G, Doney, Alexander S.F., Malik, R, Destefano, AL, Slowik, Agnieszka, Thijs, V. (Vincent), Lindgren, A., Longstreth, Wt, Nordestgaard, B.G. (Børge), Clarke, R. (Robert), Stefansson, Kan, Kostulas, K., Destefano, Anita L, Schmidt, R, Fomage, M., Farrall, Martin, Ferro, J.M., Schmidt, R. (Reinhold), Schmidt, H, WTCCC 2, Palmer, Colin N.A.; id_orcid, Helgadottir, A., Fernandez-Cadenas, Israel, Stefansson, Kari, Nordestgaard, BG, Ikram, M. Arfan, Sharma, P., Abboud, S. (Shimon), Clarke, R, Parati, EA, Gretarsdottir, Solveig, Berger, K, Hofman, A. (Albert), Palmer, C.N., Kittner, S., Algra, A, Fornage, M. (Myriam), Ringelstein, E.B. (E. Bernd), Nalls, MA, Fornage, M, O'Donnell, Martin, Longstreth, W., Kittner, T. (Thomas), Algra, A., Thorsteinsdottir, U., Kittner, S.J., Sale, Michele, Fomage, M, Reiner, A. (Alexander), Kittner, SJ, Ikram, MA, Deary, I, Worrall, B.B., Ferro, JM, Gschwendtner, Andreas, Dichgans, Martin, Holliday, E.G. (Elizabeth), Thorleifsson, G., Gschwendtner, A, Schmidt, R., de Bakker, Paul I.W., Nordestgaard, Børge G, Traylor, M. (Matthew), Mosley, T.H. (Thomas), DeStefano, Anita L., Doney, A.S.F. (Alex), Nordestgaard, Borge G., Thorleifsson, Gudmar, Yadav, S., Kostulas, K, Vicente, A.M., Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2), Psaty, BM, de Bakker, PI, Parati, Eugenio A., Saleheen, Danish, Khan, MS, Vicente, AM, Walters, M, Psaty, B.M., Hofman, A, Hopewell, Jemma C, Meschia, J.F., Pera, J., Doney, A.S.F., Mitchell, B.D., Markus, Hugh S., Kuhlenbäumer, Gregor, Hopewell, JC, Zuydam, N.R. (Natalie) van, Chen, WM, Thijs, V., Gretarsdottir, S, Yadav, Sunaina, Markus, H.S. (Hugh), Hopewell, J., Ringelstein, E. Bernd, Sudlow, Cathie, Paré, G, Montaner, Joan, Ho, W.K. (Weang Kee), Achterberg, S., Doney, Alexander S F, Seshadri, Sudha, Hopewell, J.C., Meschia, James F., Ikram, M.A. (Arfan), Malik, Rainer, Hopewell, Jemma, Traylor, Matthew +402 morecore +1 more sourceWhite Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend +8 morewiley +1 more sourceInteraction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective
Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.Aaron Rodriguez‐Calienes, Leonardo Cruz‐Criollo, Eric Kontowicz, Marta Olivé‐Gadea, Francesco Diana, Johannes Kaesmacher, Adnan Mujanovic, Serdar Geyik, Songul Senadim, Amedeo Cervo, Andrea Salcuni, Mariangela Piano, Manuel Moreu, Alfonso López‐Frías, Ameer E. Hassan, Samantha Miller, Elena Zapata‐Arriaza, Asier de Albóniga‐Chindurza, Mauro Bergui, Stefano Molinaro, João André Sousa, Fábio Gomes, João Sargento‐Freitas, Andrea Alexandre, Alessandro Pedicelli, Jeremy Hofmeister, Paolo Machi, Luca Scarcia, Erwah Kalsoum, Jose Amorim, Torcato Meira, Leonardo Renieri, Francesco Capasso, Daniele Romano, Eduardo Bárcena‐Ruiz, David Seoane, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Catarina Perry da Câmara, Anderson Brito, Nashwa Abdelhakim, Isabel Fragata, Dileep R. Yavagal, Jude H. Charles, Jose Rodriguez Castro, Pedro Vega, Atilla Özcan Özdemir, Zehra Uysal Kocabaş, Stanislas Smajda, Sadiq Al Salman, Jane Khalife, Tudor G. Jovin, Francesco Biraschi, Francesca Richetti, Pedro Castro, Luis Albuquerque, Adnan Siddiqui, Vinay Jaikumar, Pedro Navia, Nikolaos Ntoulias, Marios Psychogios, Mariano Velo, Joaquín Zamarro, Gonzalo de Paco, Yazan Ashouri, Mohammad AlMajali, Juan F. Arenillas, Alicia Sierra, Michele Romoli, João Pedro Marto, Shadi Yaghi, Marc Ribo, Alejandro Tomasello, Manuel Requena, Santiago Ortega‐Gutierrez +75 morewiley +1 more sourceUnravelling the Genetics of Ischaemic Stroke [PDF]
, 2010 Epidemiological studies suggest genetic predisposition is important in stroke risk.
Monogenic conditions are important for the individual patient but do not account for much population attributable risk. An increasing number of such conditions are being Hugh S Markus, Markus Hugh S., Markus, HS +2 morecore +1 more sourceIntegration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods
In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic +16 morewiley +1 more sourceEffects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background
Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily +5 morewiley +1 more source
