Results 21 to 30 of about 1,446,964 (268)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Island Studies. Island Geography. but What is an Island? [PDF]
Miscellanea Geographica, 2011 Island Studies. Island Geography. but What is an Island? Introduction. There are institutes which research phenomena and processes taking place on islands. Such research is conducted nowadays among others at universities in France, United States, Australia, New Zealand, Great Britain and ...
openaire +2 more sources
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Threonine 348 regulates the subcellular localization of PTEN
FEBS Open Bio, EarlyView.Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley +1 more source
Island Studies Journal 6(1), Book Reviews
Island Studies Journal, 2011 Island Studies Journal 6(1), Book reviews.
Island Studies Journal
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes +75 more
wiley +1 more source
Island Studies Journal, 14(1), Book Reviews
Island Studies Journal, 2019 Solution protocols to festering island disputes: ‘win-win’ solutions for the Diaoyu/Senkaku islands by Godfrey Baldacchino & contributors (reviewer: Romain Chuffart) Pacific futures, past and present by Warwick Anderson, Miranda Johnson, & Barbara ...
Island Studies Journal
doaj +1 more source
16. Yüzyılda Midilli Sancağı’nda Ayrıcalıklı Hizmet Sınıfı Olarak Muaf ve Müsellem Reaya
Journal of Universal History Studies, 2020 Midilli Adası ve diğer Ege Adaları, Osmanlı İmparatorluğu’nun yükselme döneminde, yüz yıla yakın bir süre içinde kesin olarak Türk egemenliği altına alınmışlardır.
Ayhan Afşin Ünal
doaj +1 more source