Results 61 to 70 of about 18,230 (249)

Xylose Metabolism Perturbation in Yarrowia lipolytica for Efficient Succinic Acid Bioproduction from Lignocellulosic Biomass

Advanced Science, EarlyView.
This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong, Changyu Shang, Jinhong Gu, Huilin Tao, Xuemei Lu, Jin Hou, Zhiyong Cui, Qingsheng Qi   +7 more
wiley   +1 more source

Protein acetylation affects acetate metabolism, motility and acid stress response in Escherichia coli

Molecular Systems Biology, 2014
Although protein acetylation is widely observed, it has been associated with few specific regulatory functions making it poorly understood. To interrogate its functionality, we analyzed the acetylome in Escherichia coli knockout mutants of cobB, the only
Sara Castaño‐Cerezo, Vicente Bernal, Harm Post, Tobias Fuhrer, Salvatore Cappadona, Nerea C Sánchez‐Díaz, Uwe Sauer, Albert JR Heck, AF Maarten Altelaar, Manuel Cánovas   +9 more
doaj   +1 more source

Bromopyrrole Alkaloids from the Sponge Agelas kosrae

Marine Drugs, 2018
Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae.
Oh-Seok Kwon, Donghwa Kim, Heegyu Kim, Yeon-Ju Lee, Hyi-Seung Lee, Chung J. Sim, Dong-Chan Oh, Sang Kook Lee, Ki-Bong Oh, Jongheon Shin   +9 more
doaj   +1 more source

Model‐Guided Systematic Metabolic Engineering for Enhanced Spinosad Biosynthesis in Saccharopolyspora spinosa NHF132

Advanced Science, EarlyView.
A genome‐scale model guided the systematic metabolic engineering of Saccharopolyspora spinosa, enabling a 5.5‐fold boost in the green bioinsecticide spinosad to 1.8 g L−1 and establishing an actinomycete framework for complex natural products overproduction.
Shuliu Wang, Yuxin Liu, Qian Zhang, Yue Jiang, Xiaoqian Zeng, Chengyu Zhang, Jiagao Cheng, Weishan Wang, Lixin Zhang, Gao‐Yi Tan   +9 more
wiley   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Electron transport phosphorylation in rumen butyrivibrios: unprecedented ATP yield for glucose fermentation to butyrate. [PDF]

, 2015
From a genomic analysis of rumen butyrivibrios (Butyrivibrio and Pseudobutyrivibrio sp.), we have re-evaluated the contribution of electron transport phosphorylation (ETP) to ATP formation in this group.
Firkins, Jeffrey L, Hackmann, Timothy J
core   +7 more sources

Localization and targeting of isocitrate lyases in Saccharomyces cerevisiae [PDF]

Biochemical Journal, 1996
Native isocitrate lyase from castor bean and a C-terminally truncated variant were expressed in Saccharomyces cerevisiae under the control of a galactose-inducible promoter. Both forms of isocitrate lyase were targeted to the yeast peroxisomes. They co-fractionated with catalase on sucrose-density-gradient centrifugation of a post-nuclear supernatant ...
Kathryn M Taylor, Claude P. Kaplan, Xiaoping Gao, Alison Baker   +3 more
openaire   +2 more sources

The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans [PDF]

, 2012
Date of Acceptance: 13/11/2012 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in ...
Ashe, Atir-Lande, Barelle, Barford, Beckwith, Brown, Buchalter, Calderone, Carlson, Cline, Crabtree, de Nobel, Ene, Enjalbert, Enjalbert, Enjalbert, Entian, Fradin, Futcher, Gancedo, Gancedo, Gancedo, Garreau, Gounalaki, Gygi, Görner, Horak, Hämmerle, Ihmels, Imbeaud, Jacob, Janke, Jiang, Johnston, Kaniak, Knop, Kusch, Lavoie, Leach, Leach, Leng, Li, Lorenz, Lorenz, López-Boado, Martchenko, Mercado, Mercado, Mercado, Merico, Nantel, Niimi, Odds, Ozcan, Piekarska, Radivojac, Ramírez, Regelmann, Rodaki, Roig, Roig, Rolland, Sabina, Scheffler, Schüle, Sherman, Smith, Stanhill, Thevelein, Thewes, Trunk, Tsong, Ueno, Usaite, Walker, Yin, Yin, Yin, Yin   +78 more
core   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zeng, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source

Oncometabolites: tailoring our genes [PDF]

, 2015
Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
core   +1 more source