Results 161 to 170 of about 23,225 (270)

Flavonoid Oxime Carbamate Derivatives: Reversal of Multidrug Resistance in Cancer Cells

open access: yesChemMedChem, Volume 21, Issue 7, 14 April 2026.
A set of 23 new flavonoid oxime carbamates was synthesized and evaluated as multidrug resistance (MDR) reversers in ABCB1‐transfected mouse lymphoma cells. All derivatives strongly inhibited P‐glycoprotein (P‐gp) efflux activity in a transport assay, while most selected compounds behaved as ATPase inhibitors. In drug combination assays, they interacted
Filipa Barbosa   +5 more
wiley   +1 more source

Covalent Protein Inhibitors via Tyrosine and Tryptophan Conjugation with Cyclic Imine Mannich Electrophiles

open access: yesAngewandte Chemie, Volume 138, Issue 15, 6 April 2026.
Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang   +6 more
wiley   +2 more sources

From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification

open access: yesChemPhysChem, Volume 27, Issue 7, 14 April 2026.
The development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Pedro Rodríguez‐Dafonte
wiley   +1 more source

Minimal N-hydroxyphthalimide-urethane bonds enable superior thermomechanical stability for covalent adaptable networks. [PDF]

open access: yesNat Commun
Yin Y   +13 more
europepmc   +1 more source

Back to the Electrofuture: Named Reactions Powered by Electroorganic Syntheses

open access: yesChemSusChem, Volume 19, Issue 7, 14 April 2026.
Bridging classical named reactions with modern electroorganic chemistry, this review presents how electrochemical strategies can revive and reinterpret historically significant transformations, highlighting their emerging potential as sustainable alternatives in contemporary organic synthesis.
Debajit Maiti   +4 more
wiley   +1 more source

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