Results 191 to 200 of about 117,884 (290)

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

The Silver Jubilee (2025) of Insulin Glargine: Introducing the Era of Long‐Acting Insulin Analogues for Diabetes Mellitus

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT In the year 2000 the first once daily long‐acting bioengineered insulin analogue (LAIA), insulin glargine (‘glargine’), a true basal insulin (BI), became available for clinical use. This led to the decline in the 50‐year‐old era and prominence of the intermediate‐acting insulins, neutral protamine Hagedorn (NPH) and lente, requiring twice ...
Geremia B. Bolli, Philip D. Home, Mauro Lepore, Matthew C. Riddle, Francesca Porcellati, Carmine G. Fanelli, Paola Lucidi, Hannele Yki‐Järvinen, Reinhard H. Becker, David R. Owens   +9 more
wiley   +1 more source

Agreement of the performance of equine electrocardiogram recording devices for ECG complexity analysis

Equine Veterinary Journal, EarlyView.
Abstract Background Non‐linear equine electrocardiography (ECG) analysis is an actively developing study area which has the potential to lead to novel, artificial intelligence‐based diagnostic tools in equine cardiology. As more ECG recording devices are becoming available, there is a need to ensure results are interchangeable regardless of the ...
Vadim Alexeenko, Dhruvpal Singh Anchan, Fe Ter Woort, Caroline Ribonnet, Emmanuele van Erck, Celia Marr, Kamalan Jeevaratnam   +6 more
wiley   +1 more source

Synthesis, Polymerization, and Assembly of Nanosilica Particles below the Isoelectric Point. [PDF]

Langmuir, 2017
Lazaro A, Vilanova N, Barreto Torres LD, Resoort G, Voets IK, Brouwers HJH.   +5 more
europepmc   +1 more source

Characterisation of a phylogenetically distinct PL25 family ulvan lyase from a seaweed biomass enriched metagenome

The FEBS Journal, EarlyView.
Ulvan is a polysaccharide available from green seaweed with beneficial properties for various applications. The full potential of ulvan requires enzymatic degradation of the polymer, thus producing ulvan oligosaccharides. This study expands the armoury of characterised ulvan lyases.
Andrius Jasilionis, Pavithra Sivakumar, Justyna M. Dobruchowska, Sune Fjermedal, Hörður Guðmundsson, Bjorn Thor Adalsteinsson, Guðmundur Ó. Hreggviðsson, Anne S. Meyer, Eva Nordberg Karlsson   +8 more
wiley   +1 more source

Light Control of Protein Solubility Through Isoelectric Point Modulation. [PDF]

J Am Chem Soc, 2017
Nadendla K, Friedman SH.
europepmc   +1 more source

CALCULATION OF ISOELECTRIC ZONES AND ISOELECTRIC POINTS

Journal of Biological Chemistry, 1936
openaire   +1 more source

Impact of Left Bundle Branch Area Pacing on Echocardiographic Parameters and Symptoms: Data From the Conduction System Pacing Italian Network Group (C‐SING) Study

Journal of Cardiovascular Electrophysiology, EarlyView.
Left bundle branch area pacing is associated with preservation of ventricular function in patients with bradycardia indications and with significant reverse remodeling and symptomatic improvement in patients with heart failure. Maintaining a high percentage of effective LBBAP capture is critical to minimize the risk of pacing‐induced cardiomyopathy and
Gabriele Dell'Era, Pietro Palmisano, Daniela Dugo, Francesco Raffaele Spera, Alessandro Paoletti Perini, Gianluca Mirizzi, Luca Poggio, Luca De Mattia, Amato Santoro, Massimo Magnano, Matteo Baroni, Francesco Solimene, Davide Castagno, Donatella Ruggiero, Luca Tomasi, Antonio Rapacciuolo, Marcello Giudice, Giovanni Rovaris, Aldo Coppolino, Renzo Venanzio Iulianella, Valerio Giordano, Alessandra Tordini, Erika Taravelli, Gennaro Miracapillo, Enrico Boggio, Mario Volpicelli, Paolo Sabbatani, Francesco Pentimalli, Gianluca Manzo, Leonardo Marinaccio, Paola Napoli, Daniele Giacopelli, Giuseppe Patti   +32 more
wiley   +1 more source

The GmGT‐2F, a trihelix transcription factor, regulates seed oil content by directly activating GmAGAL transcription in soybean

Journal of Integrative Plant Biology, EarlyView.
In soybean, the trihelix transcription factor GmGT‐2F positively regulates the expression of the α‐galactosidase gene GmAGAL, thereby modulating seed oil content. The cyclophilin GmCYP2 interacts with GmGT‐2F and suppresses GmAGAL activation. Haplotype diversity analysis of GmGT‐2F, GmCYP2, and GmAGAL identified favorable haplotype combinations ...
Shuangzhe Li, Yifan Cui, Yang Liu, Mingliang Yang, Xiaoxia Wu, Qingshan Chen, Ying Zhao   +6 more
wiley   +1 more source

Tuning the isoelectric point of graphene by electrochemical functionalization. [PDF]

Sci Rep, 2015
Zuccaro L, Krieg J, Desideri A, Kern K, Balasubramanian K.   +4 more
europepmc   +1 more source