Results 151 to 160 of about 21,511 (293)

The concentration of isoflurane in the bath, as measured by GC/MS, is plotted against the nominal concentration of isoflurane achieved by dilution of ACSF saturated with isoflurane.

, 2013
For measured values, each point represents the average of two samples taken during each isoflurane exposure (at 2 and 5 min, Figure 4). The range of values (grey shading) at each nominal concentration indicates the variability of bath isoflurane ...
Michael C. Andresen (343872), Dennis R. Koop (376508), Xin Wang (91924), Lia LaBrant (376507), James H. Peters (326250), Stuart J. McDougall (343869)   +5 more
core   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Isoflurane aggravates pre-existing proteotoxicity in adult nematodes by suppressing mitochondrial fitness

Scientific Reports
Post operative delirium (POD) is an acute complication, characterized by fluctuating attention and confusion, which may develop and persist into cognitive decline.
Tayir Elami, Huadong Zhu, Reut Bruck-Haimson, Vijigisha Srivastava, Adam Zaretsky, Irit Cohen, Einav Gross, Ehud Cohen   +7 more
doaj   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain [PDF]

, 2017
Kazuma Noguchi, Stephen A. Johnson, Gregory A. Dissen, L. Martin, Francesca M. Manzella, Katie J. Schenning, John W. Olney, Ansgar M. Brambrink   +7 more
openalex   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Isoflurane anesthesia and sleep deprivation trigger delayed and selective sleep alterations

Scientific Reports
Isoflurane anesthesia (IA) partially compensates NREM sleep (NREMS) and not REM sleep (REMS) requirement, eliciting post-anesthetic REMS rebound. Sleep deprivation triggers compensatory NREMS rebounds and REMS rebounds during recovery sleep as a result ...
Leesa Joyce, Clara Carrillo Mas, Veronica Meedt, Matthias Kreuzer, Gerhard Schneider, Thomas Fenzl   +5 more
doaj   +1 more source

Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50 [PDF]

, 2009
Tadashi Matsuura, Yutaka Oda, Katsuaki Tanaka, T Mori, K Nishikawa, Akira Asada   +5 more
openalex   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Effects of a single intravenous bolus of fentanyl on the minimum anesthetic concentration of isoflurane in chickens (Gallus gallus domesticus) [PDF]

, 2017
Rozana Wendler da Rocha, André Escobar, Bruno H. Pypendop, Darcio Zangirolami Filho, Roberto Thiesen, Fábio Nelson Gava   +5 more
openalex   +1 more source