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An integrated chemokine-based machine learning model predicts prognosis and guides immunotherapy in hepatocellular carcinoma. [PDF]
Medicine (Baltimore)Zhou J, Liu J, Wei X, Liu C, Gu H.
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The impact of lavender essential oil on the oncogenic properties of human GBM cells [PDF]
Di Bartolomeo, Sabrina +2 more
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Isoginkgetin: Advances on Resources, Bioactivity, and Pharmacology
2023Isoginkgetin (4′,4″-dimethylamentoflavone) is a dimeric flavonoid, isomer of the biflavonoid ginkgetin, after which it was named. It was first isolated from the leaves of ginkgo (Ginkgo biloba L.) and later from other plant sources, but its role in plants is still unknown. It is mainly known as a general pre-mRNA splicing inhibitor, and as such, it has
Dunja Šamec
exaly +4 more sources
Biochimica Et Biophysica Acta - Molecular Cell Research, 2021
Isoginkgetin (IGG) is a small molecule inhibitor of pre-mRNA splicing. Failure to accurately remove introns could lead to the production of aberrant mRNAs and proteins. The cellular responses to splicing stress are not well defined. Here, we used oligonucleotide microarrays to assess genome wide changes in gene expression associated with exposure to ...
Victoria Tolls, Bruce C Mckay
exaly +3 more sources
Isoginkgetin (IGG) is a small molecule inhibitor of pre-mRNA splicing. Failure to accurately remove introns could lead to the production of aberrant mRNAs and proteins. The cellular responses to splicing stress are not well defined. Here, we used oligonucleotide microarrays to assess genome wide changes in gene expression associated with exposure to ...
Victoria Tolls, Bruce C Mckay
exaly +3 more sources
Acta Biomaterialia, 2022
Doxorubicin (DOX) widely used in hepatocellular carcinoma (HCC) can induce serious side effects and drug resistance. Herein, we aimed to seek a strategy to improve the efficacy and reduce the side effects of DOX in HCC based on an autophagy inducer drug called isoginkgetin (ISO).
Meiying Wu, Lin Mei
exaly +3 more sources
Doxorubicin (DOX) widely used in hepatocellular carcinoma (HCC) can induce serious side effects and drug resistance. Herein, we aimed to seek a strategy to improve the efficacy and reduce the side effects of DOX in HCC based on an autophagy inducer drug called isoginkgetin (ISO).
Meiying Wu, Lin Mei
exaly +3 more sources
Biomedical Chromatography, 2019
AbstractIsoginkgetin is a biflavonoid compound isolated from the leaf extracts of Ginkgo biloba. In this study, an liquid chromatography–tandem mass spectrometry (LC/MS/MS) with liquid–liquid extraction was developed and validated for the analysis of isoginkgetin in rat plasma.
Weidong Xin
exaly +3 more sources
AbstractIsoginkgetin is a biflavonoid compound isolated from the leaf extracts of Ginkgo biloba. In this study, an liquid chromatography–tandem mass spectrometry (LC/MS/MS) with liquid–liquid extraction was developed and validated for the analysis of isoginkgetin in rat plasma.
Weidong Xin
exaly +3 more sources
The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing [PDF]
Journal of Biological Chemistry, 2008 Membrane-permeable compounds that reversibly inhibit a particular step in gene expression are highly useful tools for cell biological and biochemical/structural studies. In comparison with other gene expression steps where multiple small molecule effectors are available, very few compounds have been described that act as general inhibitors of pre-mRNA ...
O'Brien, Kristine +3 more
exaly +3 more sources
International Journal of Biological Macromolecules
Isoginkgetin is an edible biflavone from ginkgo biloba leaves with many bioactivities. In this work, the inhibition and synergistic effect of isoginkgetin with miglitol or acarbose on saccharomyces cerevisiae α-glucosidase (α-SCG) were tracked via various spectroscopic techniques and computer simulations.
Li Li
exaly +3 more sources
Isoginkgetin is an edible biflavone from ginkgo biloba leaves with many bioactivities. In this work, the inhibition and synergistic effect of isoginkgetin with miglitol or acarbose on saccharomyces cerevisiae α-glucosidase (α-SCG) were tracked via various spectroscopic techniques and computer simulations.
Li Li
exaly +3 more sources
Chemical Biology and Drug Design, 2022
AbstractInflammatory and invasive fibroblast‐like synoviocytes (FLS) contribute to the pathology of rheumatoid arthritis (RA). Isoginkgetin (IGKG) has been identified as having anti‐inflammatory properties. This study investigated whether IGKG could be utilized to treat RA.
Nan, Shao, Zhibo, Feng, Nannan, Li
exaly +3 more sources
AbstractInflammatory and invasive fibroblast‐like synoviocytes (FLS) contribute to the pathology of rheumatoid arthritis (RA). Isoginkgetin (IGKG) has been identified as having anti‐inflammatory properties. This study investigated whether IGKG could be utilized to treat RA.
Nan, Shao, Zhibo, Feng, Nannan, Li
exaly +3 more sources