Results 51 to 60 of about 2,274,097 (256)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Distribution of brachiopods in the Lower Visean deposits in the Eastern Urals

Литосфера, 2019
Subject. This paper is aimed at investigating the distribution of brachiopods across the stratotypes of the Lower Visean regional substages and formations, as well as of the Upper Visean Zhukovsky regional substage, which are presently located in the ...
N. A. Kucheva
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Miocene start of modern carbonate platforms

, 2019
The middle Miocene onset of modern ocean circulation patterns changed the growth style of isolated tropical carbonate platforms because surface and contour currents began shaping the flanks of these edifices. Since then, ocean currents have redistributed
Eberli, Gregor P, Betzler, Christian
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Sedimentology and chemostratigraphy of a Valanginian carbonate succession from the Baja Guajira Basin, northern Colombia

Brazilian Journal of Geology
: The Kesima Member of the Palanz Formation constitutes the first record of Cretaceous marine sedimentation along the Baja Guajira Basin, northern Colombia. Sedimentologic and petrographic analyses suggest a deposition along a coral reef dominated rimmed
Juan Carlos Silva-Tamayo, Catalina Ramirez, Mario Lara, Alcides Nobrega Sial, David Trujillo, Edward Salazar   +5 more
doaj   +1 more source

Taxonomic reassessment and palaeobiogeographical patterns of some Miogypsinidae species, larger benthic foraminifera [PDF]

Journal of Micropalaeontology
The Miogypsinidae comprise orbitoidal larger benthic foraminifera with generally eccentric position of the nepionic stage and a fan of equatorial chamberlets; the members of this family are widely used in biostratigraphy of upper Oligocene–middle Miocene
D. Bassi, J. C. Braga, S. Kinoshita, J. Pignatti, Y. Iryu, Y. Iryu   +5 more
doaj   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source