Results 91 to 100 of about 1,922,635 (306)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Conversor CC-CC trifásico ZVS PWM de três níveis [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.Esta tese propõe uma topologia de conversor CC-CC trifásico de três níveis, modulado por largura de pulso e com comutação ...
Agostini Junior, Eloi
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Power electronics for green hydrogen generation with focus on methods, topologies, and comparative analysis

Scientific Reports
This research article meticulously examines advanced power electronic converters crucial for optimizing electrolyzer perfor- mance in hydrogen production systems. It conducts a thorough review of mature electrolyzer types, detailing their specifications,
AlAmir Hassan, Omar Abdel-Rahim, Mohit Bajaj, Ievgen Zaitsev   +3 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Isolated/Non-Isolated Quad-Inverter Configuration for Multilevel Symmetrical/Asymmetrical Dual Six-Phase Star-Winding Converter [PDF]

, 2016
This article presents the developments of a novel isolated/non-isolated quad inverter configuration for multilevel dual six-phase (twelve-phase) star-winding converter. The modular circuit consists of four standard voltage source inverters (VSIs).
Khanna, Raghav, Sanjeevikumar Padmanaban, Padmanaban, Sanjeevi Kumar, Wheeler, Patrick, Blaabjerg, Frede, Blaabjerg, Frede; id_orcid, Wheeler, Patrick William, Ojo Olorunfemi, Joseph, Michael R. Hontz, Joseph Olorunfemi Ojo, Patrick William Wheeler, Padmanaban, Sanjeevikumar, Raghav Khanna, Frede Blaabjerg, Ojo, Joseph Olorunfemi, Hontz, Michael R.   +15 more
core   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

A New Non-Isolated High-Gain Single-Switch DC-DC Converter with Continuous Input Current

, 2023
A New Non-Isolated High-Gain Single-Switch DC-DC Converter with Continuous Input ...
Saman Asghari Gorji (13059219), H Gholizadeh (13364676), D Sera (13364703)   +2 more
core  

High-Voltage Gain Single-Switch Quadratic Semi-SEPIC Converters for Powering High-Voltage Sensors Suitable for Renewable Energy Systems and Industrial Automation with Low Voltage Stresses

Sensors
This paper presents two new non-isolated DC-DC converters with and without a coupled inductor based on quadratic voltage conversion. Firstly, the coupled inductor-less type is explained in detail.
Frederick Nana Oppong, Soroush Esmaeili, Ashraf Ali Khan   +2 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source