Results 111 to 120 of about 48,744 (309)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Modular, Multiport AC-DC Converter with Add-On HF Isolating Units

Energies
In this paper, we propose a novel concept of a modular, multiport, single-stage, bidirectional, isolated, three-phase AC-DC converter system. This new system is realized using add-ons to a standard voltage source inverter, including both grid-connected ...
Pawel B. Derkacz, Pawel Milewski, Daniel Wojciechowski, Natalia Strzelecka, Ryszard Strzelecki   +4 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Modeling the System for Hybrid Renewable Energy Using Highly Efficient Converters and Generator

CES Transactions on Electrical Machines and Systems
High-efficient isolated DC/DC converters with a high-efficiency synchronous reluctance generator (SRG) are the ultimate solutions in DC microgrid systems.
Tefera Kitaba
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Bidirectional DC-DC Converter Topologies for Hybrid Energy Storage Systems in Electric Vehicles: A Comprehensive Review

Energies
Electric Vehicles (EV) significantly contribute to reducing carbon emissions and promoting sustainable transportation. Among EV technologies, hybrid energy storage systems (HESS), which combine fuel cells, power batteries, and supercapacitors, have been ...
Yan Tong, Issam Salhi, Qin Wang, Gang Lu, Shengyu Wu   +4 more
doaj   +1 more source

Asymmetric snubberless current-fed full-bridge isolated DC-DC converters

Electrical, Control and Communication Engineering, 2018
This paper presents two isolated current-fed fullbridge DC-DC converters that can be used to interface a lower voltage source into a DC bus of higher voltage.
Kosenko Roman, Blinov Andrei, Vinnikov Dmitri, Chub Andrii   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

State-of-the-Art DC-DC Converters for Satellite Applications: A Comprehensive Review

Aerospace
Future manned and deep space missions require an Electrical Power System (EPS) that can deliver high power while overcoming challenges like weight and volume constraints and the harsh space environment.
Reshma Ravindran, Ahmed M. Massoud
doaj   +1 more source