Results 91 to 100 of about 48,744 (309)

Angiotensin I‐converting enzyme in isolated human glomeruli

FEBS Letters, 1987
Angiotensin I‐converting enzyme (ACE) activity was measured with hippurylhistidylleucine as a substrate in isolated human glomeruli. The mean level was 2.2±0.47 mIU/mg glomerular protein. S9780, a newly designed competitive inhibitor of ACE, inhibited this activity by 85% at 0.3 μM. [3H]S9780 specifically bound to isolated human glomeruli.
Chansel, Dominique, Morin, Jean-Paul, Borghi, Hélène, Ardaillou, Nicole, Ardaillou, Raymond   +4 more
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Z‐source‐based isolated high step‐up converter

IET Power Electronics, 2013
Continuous input currents and high step‐up ratios are desired from the dc–dc converters that work with renewable energy sources such as photovoltaic panels and fuel cells. Most dc–dc converters use transformers to have high step‐up ratios. There is another type of converters that use coupled inductors, but they need to operate at high duty cycles to ...
Evran, Fatih, Aydemir, Mehmet Timur
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dual Channel Control with DC Fault Ride Through for MMC-based, Isolated DC/DC Converter [PDF]

, 2017
This study is sponsored by the Engineering and Physical Sciences Research Council (EPSRC) grant no EP/K006428/1, 2013.D. Jovcic and H. Zhang are with the School of Engineering, University of Aberdeen, AB24 3UE, U.K.
Jovcic, Dragan, Zhang, Huibin
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Bidirectional Soft-Switched DAB-Based Single-Stage Three-Phase AC–DC Converter for V2G Application [PDF]

, 2019
In vehicle-to-grid applications, the battery charger of the electric vehicle (EV) needs to have a bidirectional power flow capability. Galvanic isolation is necessary for safety.
Baranwal, Rohit, Basu, Kaushik, Das, Dibaker, Mohan, Ned, Weise, Nathan   +4 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Review of High-Step-Up Non-Isolated DC–DC Converters Focusing on the Topology Methodology and Features

IEEE Access
Power electronic converters are essential components in modern electrical systems, with dc–dc converters being particularly crucial for their extensive variety and widespread applications, notably in renewable energy systems and electric vehicles.
Iman Soltani, Gholam Reza Molaeimanesh, Hossein Gholizadeh, Hani Vahedi   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source