Results 81 to 90 of about 1,804,197 (247)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

A Review of High-Step-Up Non-Isolated DC–DC Converters Focusing on the Topology Methodology and Features

IEEE Access
Power electronic converters are essential components in modern electrical systems, with dc–dc converters being particularly crucial for their extensive variety and widespread applications, notably in renewable energy systems and electric vehicles.
Iman Soltani, Gholam Reza Molaeimanesh, Hossein Gholizadeh, Hani Vahedi   +3 more
doaj   +1 more source

Non-Isolated Converters for Low Temperature Plasma

, 2021
The paper describes non-isolated converters for plasma torches. A high frequency was used in order to drive the pulse width modulation circuit. The average output current consumption (AOCC) was modified from (1A) up to (2A). The (AOCC) was increased from
Hakki A., Kashapov N.
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

A rectification topology for high-current isolated DC-DC converters

, 2007
This paper presents a novel current tripler rectification (CTR) topology for secondary-side rectification in high-current low-voltage isolated dc-dc converters. Compared with the conventional center-tapped and current doubler rectifiers, the CTR topology
Batarseh, Issa E., Yao, Liangbin, Mao, Hong   +2 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Comparative Performance Analysis of Isolated and Non-Isolated DC–DC Converters to Advance Electric Vehicle Charging Infrastructures

World Electric Vehicle Journal
The continued growth of electric vehicle (EV) deployment has placed increasing emphasis on the development of charging infrastructure that is efficient, reliable, and compliant with safety requirements over a wide range of power levels.
Priyanshu Kumar, Gopisetti Manikanta, Mohammed Hasmat Ali, Pulakraj Aryan, Nandini K. Krishnamurthy, Anubhav Kumar Pandey   +5 more
doaj   +1 more source

A Family of Isolated Single-Stage ZVS-PWM Active-Clamping Converters

, 2014
[[abstract]]A family of isolated single-stage ZVS-PWM active-clamping converters with high power factor are proposed. These new converters can achieve high power factor, low current harmonic distortion, tight output voltage regulation, and high ...
T.-F. Wu;S.-A. Liang;C.-H. Lee
core   +1 more source