Results 81 to 90 of about 48,744 (309)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Alone Self-Excited Induction Generators [PDF]

, 2016
In recent years, some converter structures and analyzing methods for the voltage regulation of stand-alone self-excited induction generators (SEIGs) have been introduced.
Doser, TL, Kesler, S
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Synchronous Switching Scheme - Bringing Modular Fault Tolerance to Power Converters

IEEE Open Journal of Power Electronics
Various critical applications in domains such as electric vehicles, space technology, defence, data-centers and microgrids require high power, uninterruptible and high reliability power electronic converters.
Aditya Shirodkar, Satish Naik Banavath, Andrii Chub, Riccardo Mandrioli, Mattia Ricco, Dmitri Vinnikov   +5 more
doaj   +1 more source

An On-line Diagnostic Method for Open-circuit Switch Faults in NPC Multilevel Converters [PDF]

, 2016
On-line condition monitoring is of paramount importance for multilevel converters used in safety-critical applications. A novel on-line diagnostic method for detecting open-circuit switch faults in neutral-point-clamped (NPC) multilevel converters is ...
Demerdash, Nabeel, He, Jiangbiao
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Galvanically Isolated Modular Converter

, 2018
The ever increasing penetration of renewable energy systems in the distribution grids will inevitably require profound changes in the grid infrastructure. One emerging direction, the medium voltage dc (MVdc) grids, is the cornerstone of this work. They are foreseen for offshore wind parks and onshore large scale renewables collection grids, future on ...
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A Comprehensive Review of Galvanically Isolated DC-DC Converters for Wide Voltage Gain Range Applications

IEEE Open Journal of Power Electronics
Wide voltage gain range DC-DC converters are vital in applications like photovoltaic and energy storage systems. Over the past decade, extensive research has focused on developing efficient converter topologies capable of accommodating a wide voltage ...
Salman Khan, Andrii Chub, Abualkasim Bakeer, Dmitri Vinnikov, Matthias J. Kasper, Gerald Deboy   +5 more
doaj   +1 more source