Results 71 to 80 of about 1,804,197 (247)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Comprehensive Review of Galvanically Isolated DC-DC Converters for Wide Voltage Gain Range Applications

open access: yesIEEE Open Journal of Power Electronics
Wide voltage gain range DC-DC converters are vital in applications like photovoltaic and energy storage systems. Over the past decade, extensive research has focused on developing efficient converter topologies capable of accommodating a wide voltage ...
Salman Khan   +5 more
doaj   +1 more source

Switch-mode power converters : design and analysis /

open access: yes, 2006
This book introduces an innovative, highly analytical approach to symbolic, closed-form solutions for switched-mode power converter circuits. This is a highly relevant topic to power electronics students and professionals who are involved in the design ...
Wu, Keng C.
core  

Input-output rearrangement of isolated converters

open access: yes, 2015
This paper presents a new way of rearranging the input and output of isolated converters. The new arrangement posses several advantages, as increased voltage range, higher power handling capabilities, reduced voltage stress and improved efficiency, for ...
Knott, Arnold   +11 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A Review of Galvanically Isolated Impedance-Source DC–DC Converters

open access: yes, 2016
Impedance-source converters, an emerging technology in electric energy conversion, overcome limitations of conventional solutions by the use of specific impedance-source networks.
Peng, Fang Zheng   +3 more
core   +1 more source

Non-Isolated DC-DC Converters for Renewable Energy Applications

open access: yes, 2021
Photovoltaic (PV) energy generation is an excellent example of large-scale power generation through various parallel arrangements of small voltage generating cells or modules.
Bhaskar, Mahajan Sagar   +5 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Active-clamp snubbers for isolated half-bridge DC-DC converters

open access: yes, 2005
In conventional isolated half-bridge de-dc converters, the leakage-inductance- related losses degrade converter efficiency and limit the ability to increase the converters\u27 switching frequencies. In this paper, a novel active-clamp snubber circuit for
Abu-Qahouq, Jaber   +2 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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