Results 61 to 70 of about 1,133,012 (313)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Lignans and some other non-alkaloid compounds from the stem bark of and their biological activities

open access: yesJournal of Chemical Research, 2023
Four lignans, asarinin (1) , horsfieldin (2) , 5-(4-(3,4,5-trimethoxyphenyl)hexahydrofuro[3,4-c]furan-1-yl)benzo[d][1,3]dioxole (3) , 5-(4-(3,5-dimethoxyphenyl)hexahydrofuro[3,4-c]furan-1-yl)benzo[d][1,3]dioxole (4) , and four non-alkaloid compounds ...
Tran Thi Tuyen   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Shall the Rail Lines in Isolated Territories Be Replaced by "Autonomous Vehicle Trains"? (Editorial)

open access: yes, 2021
The news that arrived on my desk forecast an increase in the size of the global rail market. The ability to meet constantly increasing demands for reduced traffic congestion and reduced journey time is now becoming our reality thanks to recent ...
Vlacic, Ljubo
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Cytotoxic and cell cycle arrest properties of two steroidal alkaloids isolated from Holarrhena floribunda (G. Don) T. Durand & Schinz leaves

open access: yesBMC Complementary and Alternative Medicine, 2019
Background The plant Holarrhena floribunda (H. floribunda; G. Don) is indigenous to sub-Saharan Africa and is traditionally used to treat several ailments.
J. A. Badmus   +4 more
doaj   +1 more source

Homozygous Transgenic Barley (Hordeum vulgare L.) Plants by Anther Culture

open access: yesPlants, 2020
Production of homozygous lines derived from transgenic plants is one of the important steps for phenotyping and genotyping transgenic progeny. The selection of homozygous plants is a tedious process that can be significantly shortened by androgenesis ...
Ludmila Ohnoutková, Tomáš Vlčko
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Avaliação da produtividade e vigor vegetativo de linhagens das cultivares catuaí vermelho e catuaí amarelo (Coffea arabica L.) plantadas individualmente e em diferentes combinações Vegetative vigor and yield evaluations of coffee cultivars, "Catuai Vermelho" and "Amarelo" (Coffea arabica L.) planted isolated and different combinations

open access: yesCiência e Agrotecnologia, 2005
Instalou-se o experimento na Fazenda Experimental da EPAMIG, em São Sebastião do Paraíso, MG, com o objetivo de avaliar a característica de produtividade de linhagens das cultivares Catuaí Vermelho (IAC 44, IAC 81 e IAC 99) e Catuaí Amarelo (IAC 47, IAC ...
Ângela Maria Nogueira   +3 more
doaj   +1 more source

Local embeddings of lines in singular hypersurfaces [PDF]

open access: yes, 1998
Lines on hypersurfaces with isolated singularities are classied New normal forms of simple singularities with respect to lines are obtained Several invariants are ...
Siersma, D.   +6 more
core   +1 more source

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