Results 91 to 100 of about 810,573 (316)

RANDOM AMPLIFIED POLYMORPHIC DNA TYPING AND PHYLOGENY OF PYTHIUM INSIDIOSUM CLINICAL ISOLATES IN THAILAND

, 2020
. Forty-three Pythium insidiosum clinical isolates recovered from human pythiosis cases in Thailand were characterized by random amplified polymorphic DNA (RAPD) analysis.
Insidiosum, Typing, Isolates, Phylogeny Of P   +3 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol [PDF]

, 2013
The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is
Kaiser Marcel, Brun Reto, de Koning Harry P., Patient Pati Pyana, Philippe Büscher, Büscher Philippe, Marcel Kaiser (41510), Mäser, Pascal, Ludin Philipp, Kaiser, Marcel, Büscher, Philippe, Harry P. de Koning (370318), Philipp Ludin, Pascal Mäser (87895), Philipp Ludin (228110), Horn David, Wenzler, Tanja, Tanja Wenzler, Patient Pati Pyana (224071), Graf, Fabrice E., David Horn, Ludin, Philipp, Marcel Kaiser, Pascal Mäser, Pyana, Patient Pati, Horn, David, David Horn (24969), Fabrice E. Graf (469055), Pyana Patient Pati, Philippe Büscher (150731), Fabrice E Graf, Wenzler Tanja, Tanja Wenzler (320253), Horn, David; id_orcid, Brun, Reto, Harry P de Koning, Graf Fabrice E., de Koning, Harry P., Reto Brun, Mäser Pascal, Reto Brun (41511)   +40 more
core   +1 more source

Characterization and Pathogenicity of the Porcine Deltacoronavirus Isolated in Southwest China

Viruses, 2019
Porcine deltacoronavirus (PDCoV) is a newly emerging enteric pathogen in swine that causes diarrhea in neonatal piglets and creates an additional economic burden on porcine industries in Asia and North America. In this study, a PDCoV isolate, CHN-SC2015,
Yujia Zhao, Huan Qu, Jingfei Hu, Jiayu Fu, Rui Chen, Cheng Li, Sanjie Cao, Yiping Wen, Rui Wu, Qin Zhao, Qigui Yan, Xintian Wen, Xiaobo Huang   +12 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Host And Temperature Preferensce, Male Occurrence And Morfomentrics Offungivorous Nematode, Aphelenchus Avenae Isolates From Japan

Jurnal Agripet, 2016
. Host and temperature preference, male accurrence, and morfomentrics of 39 isolates of Apehelenchus avenae were investigated. Of the 39 isolates, 33 were from 7 sistrict of Kyushu, 3 preference were investigated on 4 species of fungi; Botrytis cinerea ...
Buni Amin
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source