Results 81 to 90 of about 558,793 (266)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Screening of Actinomycetes from Soil for Antibacterial Activity
Nepal Journal of Biotechnology, 2020 Actinomycetes are Gram positive, free living saprophytes which are distributed in soil as one of the major populations and are primary source of antibiotics.
Shailesh Budhathoki, Anima Shrestha
doaj +1 more source
Molecular detection of tick Rhipicephalus (Boophilus) on ruminants in Mosul [PDF]
Iraqi Journal of Veterinary SciencesThe present inquiry meticulously grouped heart ticks, Rhipicephalus (Boophilus) annulatus and Rhipicephalus (Boophilus) sanguineus, based on dichotomous taxonomic key that includes number of criteria.
Layan Khalil
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Peculiarities of isolation and identification of infections rhinitis in chickens (coryza)
Ветеринария сегодня, 2018 Pathological material from poultry was subjected to bacteriological tests for infectious rhinitis in chickens. Nine Avibacteruim paragallinarum isolates were recovered from 84 samples, i.e. 10.7%.
V. A. Danilova +2 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
VIRULENCE OF INFECTIOUS CORYZA CAUSATIVE AGENT ISOLATES
Ветеринария сегодня, 2018 Virulence of 10 isolates of infectious coryza agent recovered from diseased 38-211-day-old chicken on poultry farms in the Vladimir, Moscow, Kostroma, Yaroslavl, Orenburg and Ulyanovsk Oblasts, as well as the Republic of Mordovia and Tatarstan was ...
V. A. Evgrafova, A. V. Potekhin
doaj