Results 181 to 190 of about 810,573 (316)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Failure to characterize the isolates by isoenzyme variations in plasmodium falciparum isolates

, 1995
Al-Amal Hospital, Riyadh, P. O. Box 29932, Riyadh 11467, Kingdom of Saud ArabiaIsoenzyme variation in the Sudanese isolates and the control isolates of Plasmodium falciparum Welch, 1897 was sought by starch gel electrophoresis and isoelectric focusing ...
Eligail, A.M.
core  

Investigating Stress Tolerance of Multiple <i>Salmonella enterica</i> Strains Associated With Foodborne Outbreaks. [PDF]

Int J Microbiol
Martin A, Patch C, Vanarsdall V, Pham R, Whitney G, Markus S, Lunna A, Etter AJ.   +7 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Phytophthora ramorum is a generalist plant pathogen with differences in virulence between isolates from infectious and dead-end hosts

, 2012
Variation in virulence was examined among isolates of Phytophthora ramorum from epidemiologically important or infectious (non-oak) and transmissive dead-end (oak) hosts from North America.
Hüberli, D., Garbelotto, M.
core  

In Vitro Antifungal Drug Susceptibility of Feline Sporothrix schenckii Complex Isolates, Thailand, 2023-2025. [PDF]

Emerg Infect Dis
Yurayart C, Yingchanakiat K, Thongbai A, Limsivilai O, Assawarachan SN, Jaroensong T, Sattasathuchana P.   +6 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Genomic Insights into a New Burkholderia cenocepacia Sequence Type Linked to Cepacia Syndrome in Cystic Fibrosis. [PDF]

Curr Microbiol
Xavier TS, Simão FA, Rosa HS, Colomer JCS, Cohen RW, Folescu TW, Carvalho-Assef APD, Leão RS, Marques EA.   +8 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Comparative genomics of hospital-associated vancomycin-resistant <i>Enterococcus faecium</i> from regional tertiary hospitals in Thailand. [PDF]

PeerJ
Sittiyuno C, Yingkajorn M, Chusri S, Surachat K, Chukamnerd A, Sianglum A, Nilsakul J, Mittraparp-Arthorn P, Sianglum W.   +8 more
europepmc   +1 more source