Results 201 to 210 of about 558,793 (266)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Whole Genome Characterisation of Non-O1/Non-O139 <i>Vibrio cholerae</i> in Wastewater Treatment Plants in the Tshwane District, South Africa. [PDF]

Microorganisms
Ramocha O, Mulaudzi SI, Bolukaoto JY, Rashopole S, Malemela K, Taukobong S, Nchabeleng M, Street R, Musyoki AM.   +8 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Morphological, Physiological, Pathogenic, and Molecular Characterization of <i>Colletotrichum coccodes</i> Isolates Associated with Potato Black Dot. [PDF]

Plants (Basel)
Troshin KS, Tarakanov RI, Evseev PV, Lysikova AS, Vorobev KM, Dzhalilov FS.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Antibiotic Resistance and Biofilm-Forming Capacity of Oral Biofilm Bacteria in Patients With Periodontitis and Healthy Individuals. [PDF]

Microbiologyopen
Werner N, Schöffel M, Wittmer A, Pelz K, Vach K, Frese C, von Ohle C, Wolff D, Cieplik F, Al-Ahmad A.   +9 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Frequency of Klebsiella spp. and Antimicrobial Resistance Patterns in Clinically Healthy Captive Night Monkeys (Aotus nancymaae) in the Peruvian Amazon. [PDF]

J Med Primatol
Salazar A, Sanchez-Perea N, Díaz F, Del Aguila M, Cuicapuza D, Quevedo-Urday M, Salvatierra G.   +6 more
europepmc   +1 more source

Genomic Epidemiology, Antimicrobial Resistance, and Virulence of Clinical <i>Enterococcus</i> Isolates from Hat Yai, Thailand: Genomic Relatedness and Lineage Persistence. [PDF]

Antibiotics (Basel)
Ouancharee W, Saleah S, Pomwised R, Chukamnerd A, Surachat K, Soontarach R, Singkhamanan K, Chusri S.   +7 more
europepmc   +1 more source