Results 221 to 230 of about 810,573 (316)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Emergence of Fosfomycin Resistance Among ESBL-Producing <i>Escherichia coli</i> in Abadan, Southwestern Iran. [PDF]

Health Sci Rep
Jomehzadeh N, Fakari A.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Phenotypic and genome-based characterization of <i>Klebsiella</i> species from different One Health sources in South Africa reveals the presence of multidrug-resistant isolates. [PDF]

Front Microbiol
El Zowalaty ME, Lamichhane B, Falgenhauer L, Lee DY, Eze EC, Young SG, Saleh A, Forsythe S, Zishiri OT, Lee DH, Hyeon JY, Helmy YA.   +11 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

A Fitness Burden Drives the Reversion of in vitro Acquired Doxycycline Resistance in <i>V. cholerae</i> O1. [PDF]

Infect Drug Resist
Shoukair DH, Turk AZ, Kurdi A, Matar GM, Abou Fayad AG.   +4 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Spread of carbapenemase-producing <i>Serratia</i> spp. in France from 2016 to 2024: a comparative genomic study. [PDF]

Emerg Microbes Infect
Rezzoug I, Bernabeu S, Ouacel K, Birer A, Jousset AB, Larouy-Maumus G, Bonnin RA, Emeraud C, Dortet L.   +8 more
europepmc   +1 more source