Results 231 to 240 of about 810,573 (316)

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Hospital Environment-Associated Sources of Mycobacterium abscessus Infection in Transplant Recipients.

JAMA Netw Open
Eick KL, Gan M, Thompson S, Dial CN, Deal M, DiBiase LM, Teal L, Miner TA, Chen K, Gross JE, Baker AW, Olivier KN, Miller MB, Sickbert-Bennett E, Friedland A, Liu Q.   +15 more
europepmc   +1 more source

Genomic profiling of ESBL/AmpC-producing <i>Escherichia coli</i> from backyard poultry: resistome, virulome, plasmidome, and CRISPR-Cas insights. [PDF]

Front Microbiol
Nagaraja PK, Mitra SD, Murugesan D, Muninarayanaswamy PKA, Geddam S, Venugopal N, Tewari R, Ramamurthy AS, Skariah S, Nayakvadi S, Shome BR, Shome R.   +11 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Isolation and Functional Profiling of Seed-Associated Bacteria From Rattlepods (<i>Crotalaria</i> spp.) With Biotechnological Potential. [PDF]

Int J Microbiol
Odoi BA, Nthiwa DM, Neondo JO, Muli JK, Kamau PK, Budambula NLM.   +5 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Multicenter evaluation of low inoculum and a colorimetric assay for antifungal susceptibility testing of <i>Aspergillus fumigatus</i> to echinocandins with the EUCAST E.Def 9.4. [PDF]

J Clin Microbiol
Meletiadis J, Siopi M, Meinike Jørgensen K, Escribano P, Guinea J, Arendrup MC.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparison of Phenotypic and Genotypic Antimicrobial Resistances in Bovine <i>Clostridioides difficile</i> Isolates. [PDF]

Antibiotics (Basel)
Unger I, Abdel-Glil MY, Lox J, Schmoock G, Neubauer H, Schwarz S, Seyboldt C.   +6 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source