Results 101 to 110 of about 173,598 (208)

Excitatory and inhibitory networks diverge following early blindness. [PDF]

Cereb Cortex
Laliberté G, Boire D.
europepmc   +1 more source

Centrality dependence of π, K, p production in Pb-Pb collisions at sqrt(sNN) = 2.76 TeV

, 2013
In this paper measurements are presented of π±, K±, p, and p̅ production at midrapidity (y less than 0.5), in Pb-Pb collisions at √sNN=2.76 TeV as a function of centrality.
ALICECollaboration, 안상언, 안설아, 장행진   +3 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Functionally Informed Hand Knob Reveals Structural Connectome Differences in Motor-Eloquent Tumours. [PDF]

Cancers (Basel)
Prakashvel S, Sinosi F, Ferrari L, Fayez F, Patel S, Chowdhury YA, Perera A, Kalyal N, Awan M, Diaz-Baamonde A, Mirallave-Pescador A, Ashkan K, Bhangoo R, Vergani F, Lavrador JP.   +14 more
europepmc   +1 more source

Generalized centrality in trees [PDF]

In 1982, Slater defined path subgraph analogues to the center, median, and (branch or branchweight) centroid of a tree. We define three families of central substructures of trees, including three types of central subtrees of degree at most D that yield ...
Pelsmajer, M.J., Mulder, H.M., Reid, K.B.   +2 more
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Optimization of polyethylene glycol-based isolation of exosomes from mesenchymal stem cells for regenerative medicine applications. [PDF]

Stem Cell Res Ther
Adelipour M, Hwang H, Marzouk RM, Gab-Allah MA, Lee GS, Moon JH, Kim KK, Lubman DM, Kim J.   +8 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Kernel-Weighted Aggregation for Hyperparameter-Free Quantum Federated Learning. [PDF]

Entropy (Basel)
Huang R.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source