Results 81 to 90 of about 173,598 (208)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The dynamics of closeness and betweenness [PDF]
Although both betweenness and closeness centrality are claimed to be important for the effectiveness of someones network position, it has not been explicitly studied which networks emerge if actors follow incentives for these two positional advantages ...
Vincent Buskens, Berno Buechel
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Centrality measures for immunization of weighted networks [PDF]
, 2016 Effective immunization of individual communities with minimal cost in vaccination has made great discussion surrounding the realm of complex networks.
Mohammad Khansari +2 more
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Nestedness in Networks: A Theoretical Model and Some Applications [PDF]
We develop a dynamic network formation model that can explain the observed nestedness in real-world networks. Links are formed on the basis of agents’ centrality and have an exponentially distributed life time. We use stochastic stability to identify the
Yves Zenou +2 more
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The dynamics of closeness and betweenness [PDF]
, 2008 Buechel B, Buskens V. The dynamics of closeness and betweenness. Working Papers. Institute of Mathematical Economics. Vol 398. Bielefeld: Universität Bielefeld; 2008.Although both betweenness and closeness centrality are claimed to be important for the ...
Buechel, Berno, Buskens, Vincent
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Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
The Impacts of Airport Centrality in the EU Network and Inter- Airport Competition on Airport Efficiency [PDF]
In this paper we study the relationship between airport efficiency and two factors: an airport’s centrality in the EU network, and the intensity of competition from alternative airports in the same catchment area.
Paleari, S +3 more
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