Results 41 to 50 of about 33,607 (264)
CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives
Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis +17 morewiley +1 more sourceGluon Saturation Effects in Relativistic U+U Collisions
, 2006 We examine entropy production in relativistic U+U collisions on the basis of
a Color Glass Condensate (CGC) type picture as implemented in the
Kharzeev-Levin-Nardi model (KLN).Adams, Adcox, Adil, Anthony Kuhlman, Arsene, Back, Back, Gribov, Heinz, Hirano, Hirano, Iancu, Jalilian-Marian, Kharzeev, Kharzeev, Kharzeev, Kharzeev, Kolb, Kolb, Kolb, Krasnitz, Kuhlman, Li, Nepali, Shuryak, Ulrich Heinz, Yuri V. Kovchegov +26 morecore +1 more sourceMapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI) Dong‐Woo Shin, Tingting Chen, James A. Letts +2 morewiley +1 more sourceLIG1 is a novel marker for bladder cancer prognosis: evidence based on experimental studies, machine learning and single-cell sequencing
Frontiers in ImmunologyBackgroundBladder cancer, a highly fatal disease, poses a significant threat to patients. Positioned at 19q13.2-13.3, LIG1, one of the four DNA ligases in mammalian cells, is frequently deleted in tumour cells of diverse origins.Ding-ming Song, Tong Shen, Kun Feng, Yi-bo He, Shi-liang Chen, Yang Zhang, Wen-fei Luo, Lu Han, Ming Tong, Yanyang Jin +9 moredoaj +1 more sourceBeam-Energy Dependence of Directed Flow of Protons, Antiprotons and
Pions in Au+Au Collisions [PDF]
, 2014 Rapidity-odd directed flow($v_1$) measurements for charged pions, protons and
antiprotons near mid-rapidity ($y=0$) are reported in $\sqrt{s_{NN}} =$ 7.7,
11.5, 19.6, 27, 39, 62.4 and 200 GeV Au + Au collisions as recorded by the STAR
detector at the ...Adamczyk, L., Adkins, J. K., Agakishiev, G., Aggarwal, M. M., Ahammed, Z., Alekseev, I., Alford, J., Anson, C. D., Aparin, A., Arkhipkin, D., Aschenauer, E. C., Averichev, G. S., Banerjee, A., Beavis, D. R., Bellwied, R., Bhasin, A., Bhati, A. K., Bhattarai, P., Bichsel, H., Bielcik, J., Bielcikova, J., Bland, L. C., Bordyuzhin, I. G., Borowski, W., Bouchet, J., Brandin, A. V., Brovko, S. G., Bunzarov, I., Burton, T. P., Butterworth, J., Bültmann, S., Caines, H., Cebra, D., Cendejas, R., Cervantes, M. C., Chaloupka, P., Chang, Z., Chattopadhyay, S., Chen, H. F., Chen, J. H., Chen, L., Cheng, J., Cherney, M., Chikanian, A., Christie, W., Chwastowski, J., Codrington, M. J. M., Contin, G., Cramer, J. G., Crawford, H. J., Cui, X., Das, S., De Silva, L. C., de Souza, R. Derradi, Debbe, R. R., Dedovich, T. G., Deng, J., Derevschikov, A. A., Dhamija, S., di Ruzza, B., Didenko, L., Dilks, C., Ding, F., Djawotho, P., Don, D. M. M. D. Madagodagettige, Dong, X., Drachenberg, J. L., Draper, J. E., Du, C. M., Dunkelberger, L. E., Dunlop, J. C., Efimov, L. G., Engelage, J., Engle, K. S., Eppley, G., Eun, L., Evdokimov, O., Eyser, O., Fatemi, R., Fazio, S., Fedorisin, J., Filip, P., Finch, E., Fisyak, Y., Flores, C. E., Gagliardi, C. A., Gangadharan, D. R., Garand, D., Geurts, F., Gibson, A., Girard, M., Gliske, S., Greiner, L., Grosnick, D., Gunarathne, D. S., Guo, Y., Gupta, A., Gupta, S., Guryn, W., Haag, B., Hamed, A., Han, L-X., Haque, R., Harris, J. W., Heppelmann, S., Hirsch, A., Hoffmann, G. W., Hofman, D. J., Horvat, S., Huang, B., Huang, H. Z., Huang, X., Huck, P., Humanic, T. J., Igo, G., Jacobs, W. W., Jang, H., Judd, E. G., Kabana, S., Kalinkin, D., Kang, K., Kauder, K., Ke, H. W., Keane, D., Kechechyan, A., Kesich, A., Khan, Z. H., Kikola, D. P., Kisel, I., Kisiel, A., Koetke, D. D., Kollegger, T., Konzer, J., Koralt, I., Kotchenda, L., Kraishan, A. F., Kravtsov, P., Krueger, K., Kulakov, I., Kumar, L., Kycia, R. A., Lamont, M. A. C., Landgraf, J. M., Landry, K. D., Lauret, J., Lebedev, A., Lednicky, R., Lee, J. H., LeVine, M. J., Leyva, A. Davila, Li, C., Li, W., Li, X., Li, X., Li, Y., Li, Z. M., Lisa, M. A., Liu, F., Ljubicic, T., Llope, W. J., Lomnitz, M., Longacre, R. S., Luo, X., Ma, G. L., Ma, Y. G., Mahapatra, D. P., Majka, R., Margetis, S., Markert, C., Masui, H., Matis, H. S., McDonald, D., McShane, T. S., Minaev, N. G., Mioduszewski, S., Mohanty, B., Mondal, M. M., Morozov, D. A., Mustafa, M. K., Nandi, B. K., Nasim, Md., Nayak, T. K., Nelson, J. M., Nigmatkulov, G., Nogach, L. V., Noh, S. Y., Novak, J., Nurushev, S. B., Odyniec, G., Ogawa, A., Oh, K., Ohlson, A., Okorokov, V., Oldag, E. W., Olvitt Jr., D. L., Pachr, M., Page, B. S., Pal, S. K., Pan, Y. X., Pandit, Y., Panebratsev, Y., Pawlak, T., Pawlik, B., Pei, H., Perkins, C., Peryt, W., Pile, P., Planinic, M., Pluta, J., Poljak, N., Porter, J., Poskanzer, A. M., Pruthi, N. K., Przybycien, M., Pujahari, P. R., Putschke, J., Qiu, H., Quintero, A., Ramachandran, S., Raniwala, R., Raniwala, S., Ray, R. L., Riley, C. K., Ritter, H. G., Roberts, J. B., Rogachevskiy, O. V., Romero, J. L., Ross, J. F., Roy, A., Ruan, L., Rusnak, J., Rusnakova, O., Sahoo, N. R., Sahu, P. K., Sakrejda, I., Salur, S., Sandweiss, J., Sangaline, E., Sarkar, A., Schambach, J., Scharenberg, R. P., Schmah, A. M., Schmidke, W. B., Schmitz, N., Seger, J., Seyboth, P., Shah, N., Shahaliev, E., Shanmuganathan, P. V., Shao, M., Sharma, B., Shen, W. Q., Shi, S. S., Shou, Q. Y., Sichtermann, E. P., Singaraju, R. N., Skoby, M. J., Smirnov, D., Smirnov, N., Solanki, D., Sorensen, P., Spinka, H. M., Srivastava, B., Stanislaus, T. D. S., STAR Collaboration, Stevens, J. R., Stock, R., Strikhanov, M., Stringfellow, B., Sumbera, M., Sun, X., Sun, X. M., Sun, Y., Sun, Z., Surrow, B., Svirida, D. N., Symons, T. J. M., Szelezniak, M. A., Sánchez, M. Calderón de la Barca, Takahashi, J., Tang, A. H., Tang, Z., Tarnowsky, T., Thomas, J. H., Timmins, A. R., Tlusty, D., Tokarev, M., Trentalange, S., Tribble, R. E., Tribedy, P., Trzeciak, B. A., Tsai, O. D., Turnau, J., Ullrich, T., Underwood, D. G., Van Buren, G., van Nieuwenhuizen, G., Vandenbroucke, M., Vanfossen, Jr., J. A., Varma, R., Vasconcelos, G. M. S., Vasiliev, A. N., Vertesi, R., Videbæk, F., Viyogi, Y. P., Vokal, S., Vossen, A., Wada, M., Wang, F., Wang, G., Wang, H., Wang, J. S., Wang, X. L., Wang, Y., Wang, Y., Webb, G., Webb, J. C., Westfall, G. D., Wieman, H., Wissink, S. W., Witt, R., Wu, Y. F., Xiao, Z., Xie, W., Xin, K., Xu, H., Xu, J., Xu, N., Xu, Q. H., Xu, Y., Xu, Z., Yan, W., Yang, C., Yang, Y., Yang, Y., Ye, Z., Yepes, P., Yi, L., Yip, K., Yoo, I-K., Yu, N., Zawisza, Y., Zbroszczyk, H., Zha, W., Zhang, J. B., Zhang, J. L., Zhang, S., Zhang, X. P., Zhang, Y., Zhang, Z. P., Zhao, F., Zhao, J., Zhong, C., Zhu, X., Zhu, Y. H., Zoulkarneeva, Y., Zyzak, M. +356 morecore +3 more sourcesPhosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia +3 morewiley +1 more source