Results 131 to 140 of about 2,248,440 (315)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Brain SciencesBackground/Objectives: Attentional bias toward drug-related cues is a characteristic of drug dependence and plays a detrimental role during drug withdrawal. The present study examined attentional bias in female individuals with drug dependence.
Biye Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Social Isolation and Inequality [PDF]
There is an increasing interest in the concept of social exclusion and the related concept of social isolation and their potential role in understanding inequality.
Dan Silverman, Andrew Postlewaite
core +2 more sources
Identification of safety-relevant radionuclides for performance assessment modeling
Frontiers in Nuclear EngineeringWe propose, apply, and verify a screening approach for the selection of safety-relevant radionuclides that should be tracked in models assessing the performance of geologic repositories for the disposal of spent nuclear fuel and high-level radioactive ...
Stefan Finsterle +2 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Research on drug addiction detection based on AR-TSNET with bimodal EEG–NIRS
BioMedical Engineering OnLineTraditional research on drug addiction assessment relies primarily on psychological scales, self-reports from drug users, and subjective judgments from doctors, ands lacks objective physiological indicators and quantitative evaluation.
Xiaowen Zhang +5 more
doaj +1 more source
, 2018 <p>Work done at Hiroshima University in collaboration with Prof. Toru Nakanishi and Yoshino Hiromi. An implementation of a Zero-Knowledge proof of vertex isolation using accumulators and a few bilinear pairing operations.</p ...
Guru Vamsi Policharla
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source