Results 131 to 140 of about 1,454,719 (345)

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

open access: yesAdvanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li   +8 more
wiley   +1 more source

Engineering Decavalent, Sperm‐Binding Laminin‐IgG Hybrid Antibodies for Potent Non‐Hormonal Contraception

open access: yesAdvanced Science, EarlyView.
This study investigates a highly multivalent mAb platform fusing Laminin‐511 heterotrimerization domains with Fabs and IgG1‐Fc as a non‐hormonal contraceptive. The most potent molecule ‘LamH10’, possessing 10 Fabs, rapidly achieved >99% reduction in progressively motile sperm at just 33µg per dose in sheep, making the laminin‐IgG hybrid platform the ...
Alison Schaefer   +8 more
wiley   +1 more source

Recent Advances of Microcapsule‐based Intelligent Coatings: From Bioinspired Designs, Material Selections, to Potential Applications

open access: yesAdvanced Science, EarlyView.
Microcapsule‐based intelligent coatings (MICs) have shown great potential in the fields of biomedicine, smart buildings, marine protection, and aerospace. However, they currently face challenges in the integration of coating functions and applications in complex systems.
Yue Zhao   +5 more
wiley   +1 more source

Deep Learning‐Assisted Rapid Bacterial Classification Based on Raman Spectroscopy of Bacteria Lysed by Acoustically Driven Fiber‐Tip Vibration

open access: yesAdvanced Science, EarlyView.
A novel acoustofluidic lysis technique based on a vibrating fiber‐tip is integrated with Raman spectroscopy and deep learning for rapid, label‐free bacterial classification. By exposing intracellular biomolecules, this method significantly enhances spectral resolution, enabling high‐accuracy classification with a 1D‐ResNet model.
Yukai Liu   +9 more
wiley   +1 more source

Reply to “Exploring Bacteria‐Based Cancer Immunotherapy”—Comment on “Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics”

open access: yesAdvanced Science, EarlyView.
Abstract This manuscript is a formal response to the commentary by A/Prof. Dr. Chen‐xi Li and colleagues regarding our previous publication in Advanced Science. We clarify the rationale, methods, and outcomes of our original study and highlight ongoing work in the field of bacterial cancer immunotherapy.
Eijiro Miyako
wiley   +1 more source

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