Results 161 to 170 of about 116,201 (210)

Isoleucine-to-valine substitutions support cellular physiology during isoleucine deprivation [PDF]

Nucleic Acids Research
Abstract Aminoacyl-tRNA synthetases (ARSs) couple tRNAs with their corresponding amino acids. While ARSs can bind structurally similar amino acids, extreme specificity is ensured by subsequent editing activity. Yet, we found that upon isoleucine (I) restriction, healthy fibroblasts consistently incorporated valine (V) into proteins at ...
Holger Rehmann, Edward E S Nieuwenhuis, Gautam Kok   +2 more
exaly   +7 more sources

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine [PDF]

Cell Metabolism, 2021
Low protein diets promote metabolic health in rodents and humans, and the benefits of low protein diets are recapitulated by specifically reducing dietary levels of the three branched-chain amino acids (BCAAs), leucine, isoleucine, and valine.
Deyang Yu, Nicole E Richardson, Cara L Green   +2 more
exaly   +2 more sources

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Inhibition of Escherichia coli isoleucine biosynthesis by isoleucine tetrazole

Journal of Bacteriology, 1975
Growth of a derivative of Escherichia coli K-10 was strongly inhibited by 2 times 10(-4) M L-5(1-amino-2-methylbutyl)-tetrazole (isoleucine tetrazole). Growth inhibition was reversed by isoleucine, threonine, glycyl-L-isoleucine, or glycyl-L-threonine, and, in a valine-resistant mutant, by L-valine.
G A, Willshaw, H, Tristram
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Isoleucine and Allo-isoleucine

Nature, 1958
DURING our investigations on amino-acid analysis on ion exchange resins using Moore and Stein's method1, it was seen that in a synthetic mixture of 13 amino-acids (Hoffmann-LaRoche, mostly in the l-configuration) the ‘methionine’ recovery was always too high (120–150 per cent of the theoretical amount) and the ‘isoleucine’ recovery always too low (65 ...
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Glial Metabolism of Isoleucine

Neurochemical Research, 2008
Isoleucine, together with leucine and valine, constitutes the group of branched-chain amino acids (BCAAs). BCAAs are transported from the blood into the brain parenchyma, where they can serve several distinct functions. Since brain tissue is known to oxidatively metabolize BCAAs to CO(2), they are considered as fuel material in brain energy metabolism.
Radovan, Murín, Ghasem, Mohammadi, Dieter, Leibfritz, Bernd, Hamprecht   +3 more
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Biological availability of isoleucine

Archives of Biochemistry and Biophysics, 1957
Abstract Biological availability of isoleucine in eight different proteins was determined using a blood meal diet low in isoleucine. Isoleucine in zein was available to the extent of 30%; in casein and gelatin, around 60–70%; and in fibrin, beef, egg albumin, and Drackett, over 90% of the isoleucine was available to the rat.
P D, DESHPANDE, A E, HARPER, M, COLLINS, C A, ELVEHJEM   +3 more
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Regulation of Isoleucine and Valine Biosynthesis

1978
Publisher Summary This chapter discusses the regulation of isoleucine and valine biosynthesis. Isoleucine and valine biosynthesis is a model system for the study of mechanisms by which the cell coordinates different parts of its total metabolism. Threonine deaminase is the first enzyme in isoleucine biosynthesis.
Iaccarino M., Guardiola J., DE FELICE, MAURILIO, Favre R.   +3 more
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Memory of Chirality in Diastereoselective α-Alkylation of Isoleucine and allo-Isoleucine Derivatives

Organic Letters, 2000
[reaction: see text] alpha-Methylation of 3 gave 5 as a major product whereas 4 gave 6 predominantly, although both 3 and 4 have an (S)-chiral center at C(3). This indicates that chirality at C(2) in 3 and 4 was memorized in the corresponding intermediate enolates and the induced chirality made a major contribution in the stereochemical course of the ...
T, Kawabata, J, Chen, H, Suzuki, Y, Nagae, T, Kinoshita, S, Chancharunee, K, Fuji   +6 more
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Synthesis and pharmacological properties of [5-isoleucine]-, [8-isoleucine]-, and [5,8-diisoleucine]bradykinin

Journal of Medicinal Chemistry, 1979
Three bradykinin analogues have been synthesized in which the phenylalanine residue(s) at positions 5 and/or 8 have been substituted by isoleucine. All these analogues have weak bradykinin-like activity in isolated rat uterine smooth muscle or in rat blood pressure assay. No antagonistic activity was observed with any of these analogues. The importance
A T, Chiu, A R, Day, J A, Radding, R J, Freer   +3 more
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Isoleucine production in bifidobacteria

European Journal Of Applied Microbiology, 1976
About 300 strains of bifidobacteria were examined for their capacity to release L-isoleucine in the fermentation broth. A strain of the speciesBifidobacterium ruminale was selected as the best producer. After treatment of this strain with NTG a DL-α-aminobutyric acid-resistant mutant capable of producing about 5 mg/ml of L-isoleucine in presence of 1.5
D. Matteuzzi, Franca Crociani, O. Emaldi, Annarosa Selli, R. Viviani   +4 more
openaire   +1 more source