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Inhibition of Escherichia coli isoleucine biosynthesis by isoleucine tetrazole

Journal of Bacteriology, 1975
Growth of a derivative of Escherichia coli K-10 was strongly inhibited by 2 times 10(-4) M L-5(1-amino-2-methylbutyl)-tetrazole (isoleucine tetrazole). Growth inhibition was reversed by isoleucine, threonine, glycyl-L-isoleucine, or glycyl-L-threonine, and, in a valine-resistant mutant, by L-valine.
G A, Willshaw, H, Tristram
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Isoleucine and Allo-isoleucine

Nature, 1958
DURING our investigations on amino-acid analysis on ion exchange resins using Moore and Stein's method1, it was seen that in a synthetic mixture of 13 amino-acids (Hoffmann-LaRoche, mostly in the l-configuration) the ‘methionine’ recovery was always too high (120–150 per cent of the theoretical amount) and the ‘isoleucine’ recovery always too low (65 ...
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Glial Metabolism of Isoleucine

Neurochemical Research, 2008
Isoleucine, together with leucine and valine, constitutes the group of branched-chain amino acids (BCAAs). BCAAs are transported from the blood into the brain parenchyma, where they can serve several distinct functions. Since brain tissue is known to oxidatively metabolize BCAAs to CO(2), they are considered as fuel material in brain energy metabolism.
Radovan, Murín   +3 more
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Biological availability of isoleucine

Archives of Biochemistry and Biophysics, 1957
Abstract Biological availability of isoleucine in eight different proteins was determined using a blood meal diet low in isoleucine. Isoleucine in zein was available to the extent of 30%; in casein and gelatin, around 60–70%; and in fibrin, beef, egg albumin, and Drackett, over 90% of the isoleucine was available to the rat.
P D, DESHPANDE   +3 more
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Isoleucine requirements of the chicken: The effect of excess leucine and valine on the response to isoleucine

British Poultry Science, 1992
1. Three experiments were designed to determine the response of broiler chickens to dietary isoleucine, and to quantify the antagonistic effects of excess leucine and valine on this response. 2. A dilution technique was used to measure the responses in growth rate and food intake to a range of diets differing in their isoleucine concentrations.
Burnham, D., Gous, R. M., Emmans, G. C.
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Regulation of Isoleucine and Valine Biosynthesis

1978
Publisher Summary This chapter discusses the regulation of isoleucine and valine biosynthesis. Isoleucine and valine biosynthesis is a model system for the study of mechanisms by which the cell coordinates different parts of its total metabolism. Threonine deaminase is the first enzyme in isoleucine biosynthesis.
Iaccarino M.   +3 more
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Memory of Chirality in Diastereoselective α-Alkylation of Isoleucine and allo-Isoleucine Derivatives

Organic Letters, 2000
[reaction: see text] alpha-Methylation of 3 gave 5 as a major product whereas 4 gave 6 predominantly, although both 3 and 4 have an (S)-chiral center at C(3). This indicates that chirality at C(2) in 3 and 4 was memorized in the corresponding intermediate enolates and the induced chirality made a major contribution in the stereochemical course of the ...
T, Kawabata   +6 more
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Synthesis and pharmacological properties of [5-isoleucine]-, [8-isoleucine]-, and [5,8-diisoleucine]bradykinin

Journal of Medicinal Chemistry, 1979
Three bradykinin analogues have been synthesized in which the phenylalanine residue(s) at positions 5 and/or 8 have been substituted by isoleucine. All these analogues have weak bradykinin-like activity in isolated rat uterine smooth muscle or in rat blood pressure assay. No antagonistic activity was observed with any of these analogues. The importance
A T, Chiu   +3 more
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