Results 301 to 310 of about 197,005 (375)

Characterization of a duck circovirus propagated in duck embryos: from genome to pathogenesis in SPF ducks. [PDF]

Poult Sci
Guo X, Liu L, Zhu T, Gao Y, Yin D, Ma X, Huang B, Li Y, Qin Z, Hu F, Yu K.   +10 more
europepmc   +1 more source

Amino Acid Biosynthesis in the Spirochete Leptospira : Evidence for a Novel Pathway of Isoleucine Biosynthesis

, 1974
Nyles W. Charon, Russell C. Johnson, David Peterson   +2 more
openalex   +1 more source

Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) sequesters misfolded proteins during stress

The FEBS Journal, EarlyView.
Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) is a major co‐chaperone to both Hsp90 and Hsp70. We find that misbalanced expression of Sti1 in yeast and mammalian cells causes severe growth defects. Deletion of STI1 causes an accumulation of soluble misfolded ubiquitinated proteins and a strong activation of the heat shock response.
Benjamin S. Rutledge, Young J. Kim, Donovan W. McDonald, Juan C. Jurado‐Coronel, Marco A. M. Prado, Jill L. Johnson, Wing‐Yiu Choy, Martin L. Duennwald   +7 more
wiley   +1 more source

Associations between amino acid levels and autism spectrum disorder severity. [PDF]

BMC Psychiatry
Li J, Zhai P, Bi L, Wang Y, Yang X, Yang Y, Li N, Dang W, Feng G, Li P, Liu Y, Zhang Q, Mei X.   +12 more
europepmc   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Narrow-spectrum resource-utilizing bacteria drive the stability of synthetic communities through enhancing metabolic interactions. [PDF]

Nat Commun
Wang W, Xia Y, Zhang P, Zhu M, Huang S, Sun X, Xu Z, Zhang N, Xun W, Shen Q, Miao Y, Zhang R.   +11 more
europepmc   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

A narrative review of metabolomics approaches in identifying biomarkers of doxorubicin-induced cardiotoxicity. [PDF]

Metabolomics
Singh A, Bakhtyar M, Jun SR, Boerma M, Lan RS, Su LJ, Makhoul S, Hsu PC.   +7 more
europepmc   +1 more source

Identification of CO‐binding modes in the CuB site of bovine cytochrome c oxidase by spatial mapping of binding energy

The FEBS Journal, EarlyView.
Quantum simulations of the catalytic center (CuB) of cytochrome c oxidase, driving the electron transport system, revealed a crucial role of Val243 in modulation of ligand binding. Val243‐driven interaction facilitates hybridization between CO and Fe orbitals, thus highlighting Val243's impact on electronic structure and ligand dynamics.
Jiyoung Kang, Toru Matsuoka, Masaru Tateno   +2 more
wiley   +1 more source

Valine deficiency has a greater impact on broiler growth and bone health than isoleucine deficiency. [PDF]

Poult Sci
Goo D, Kim WK.
europepmc   +1 more source