Results 141 to 150 of about 17,636 (275)

Proximity‐Induced Protein Deglycosylation by Endogenous O‐GlcNAcase

Angewandte Chemie, EarlyView.
Bifunctional molecules recruit endogenous O‑GlcNAcase to target proteins, enabling selective de‑O‑GlcNAcylation in living cells without perturbing global O‑GlcNAc homeostasis. This work developed a programmable chemical strategy for targeted O‑GlcNAc editing and framework for functional enzymatic recruitment via optimization of competitive enzyme ...
Haixing Xu, Bowen Ma, Yunpeng Huang, Jialin Liu, Billy Wai‐Lung Ng   +4 more
wiley   +2 more sources

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Supramolecular Cadmium‐Telluride Proteoliposomal Assemblies for Real‐Time Detection of Protein‐Catalyzed Pt(II)‐Complexes Transmembrane Translocation: Cu(I)‐Pumps Are Electrogenic Pt(II)‐Drug Uniporters

Angewandte Chemie, EarlyView.
Supramolecular mercaptosuccinic acid‐capped CdTe core‐type quantum dot‐encapsulated proteoliposome assemblies (MSA‐CdTe QD PLs) have been developed to study and unambiguously demonstrate real‐time transporter‐mediated turnover translocation of Pt(II)‐based complexes by transmembrane Cu(I) P‐type ATPase pumps (CopA).
Madujika A. Horadigala Gamage, Alessandra Barbanente, Nadeesha T. Liyana Withanage, Yalini H. Wijesundara, Jeremiah J. Gassensmith, Fabio Arnesano, Giovanni Natile, Gabriele Meloni   +7 more
wiley   +2 more sources

Various Hepatic Fibrosis Markers Should Be Evaluated for Causing Complications After Hepatectomy

Annals of Gastroenterological Surgery, EarlyView.
Toru Ikegami, Hiroshi Nakanishi, Kanako Maeda, Kenei Furukawa   +3 more
wiley   +1 more source

Second‐Sphere Aromatic Substitutions That Tune H‐Atom Transfer Reactivity Observed for a Series of S = 1 Nonheme FeIV=O Complexes: An Enthalpy‐Entropy Compensation Effect

Angewandte Chemie, EarlyView.
A series of oxoiron(IV) complexes was synthesized to determine the impact of electronically tuned aromatic substitution in the secondary sphere of the ligand. Despite possessing identical electronic properties, they show significant differences in C─H oxidation reactions.
Abhishek Das, Jin Xiong, Victor G. Young Jr., Yisong Guo, Marcel Swart, Lawrence Que Jr.   +5 more
wiley   +1 more source

Double Reduction of Ph3B to a Dianionic Borane With a Powerful SrI Intermediate

Angewandte Chemie, EarlyView.
Although dianionic boranes follow the octet rule and are isoelectronic to carbanions or amines, the high electron density combined with the electropositive nature of the B center make them highly unstable species. In this study, we present synthesis and full characterization of a complex in which Ph3B2− is sandwiched between two Sr2+ ions and describe ...
Michael Morasch, Marcel A. Schmidt, Tanuja Tewari, Jens Langer, Sjoerd Harder   +4 more
wiley   +2 more sources

Redshifting TADF Emission With a Bora‐Triptycene Lewis Acid

Angewandte Chemie, EarlyView.
Bathochromic emission shifting of donor–acceptor and multi‐resonant TADF emitters is achieved by adduct formation with a thia‐bora‐triptycene Lewis acid. TADF properties are retained on adduct formation whilst delivering > 100 nm redshift of the emission.
Mathew J. Cross, Emily L. Hanover, Arnaud Osi, Eli Zysman‐Colman, Michael J. Ingleson   +4 more
wiley   +2 more sources

A fetus with meckel-gruber syndrome associated with isomerism

Open Medicine, 2014
Kitova Tanya, Kilova Kristina, Kitov Borislav, Masmoudi Aida, Milkov Denis, Gaigi Soumeya   +5 more
doaj   +1 more source

Atrial isomerism

The Journal of Thoracic and Cardiovascular Surgery, 1989
openaire   +2 more sources

Methane Activation by B5+ Toward a CB5H2+ Isomer Containing a Planar Tetracoordinate Carbon Atom

Angewandte Chemie, EarlyView.
Methane activation by B5+ yields CB5H2+ through H2 elimination. Electronic‐structure calculations connect the nascent dehydrogenation product to a low‐lying isomer containing a planar tetracoordinate carbon atom. ABSTRACT Planar tetracoordinate carbon (ptC) motifs have been identified predominantly in the global‐minimum structures of gas‐phase clusters
Qin‐Wei Zhang, Qiang Chen, Fernando Murillo, Filiberto Ortíz‐Chi, Rui‐Nan Yuan, Fernando Martínez‐Villarino, Aura Gómez‐Heredia, Hong Niu, Rui Wei, Jiao‐Jiao Chen, Yan‐Bo Wu, Gabriel Merino   +11 more
wiley   +1 more source