Results 91 to 100 of about 56,897 (225)
Pharmacogenetics of ophthalmic topical β-blockers [PDF]
, 2008 Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure.
McCarty, Catherine A. +4 more
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Journal of Fish Biology, EarlyView.Abstract Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to ...
Emily P. Williams +6 more
wiley +1 more source
Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases [PDF]
, 2019 Heart failure (HF) is a highly complex disorder and a major end-point of cardiovascular diseases (CVD). The pathogenesis of HF is mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell ...
Kasi Ganeshan, T., Kasi Ganeshan, T.
core
Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia [PDF]
, 2018 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine receptor (RyR2 ...
Belevych, Andriy E +12 more
core +1 more source
Frontiers in Physiology, 2017 Background: We previously reported that lysophosphatidic acid (LPA) promoted cardiomyocyte hypertrophy in vitro via one of its G protein-coupled receptor subtypes, LPA3.
Lin Cai +7 more
doaj +1 more source
Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception
Orthodontics &Craniofacial Research, EarlyView.ABSTRACT Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial ...
Brian Edwin Cairns
wiley +1 more source
ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells. [PDF]
, 2017 FRET and BRET approaches are well established for detecting ligand induced GPCR-G protein interactions in cells. Currently, FRET/BRET assays rely on co-expression of GPCR and G protein, and hence depend on the stoichiometry and expression levels of the ...
Dysthe, Matthew +4 more
core +1 more source
Experimental Physiology, EarlyView.Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su +4 more
wiley +1 more source
Frontiers in Physiology, 2018 Different human-like cardiomyopathies associated to β-adrenergic stimulation are experimentally modeled in animals through variations in dose, route, and duration of administration of different cardiotoxic drugs.
Betzabé Nieto-Lima +4 more
doaj +1 more source
Metabolic and functional consequences of cytosolic 5′-nucleotidase-IA overexpression in neonatal rat cardiomyocytes [PDF]
, 2003 Adenosine exerts a spectrum of energy-preserving actions on the heart negative chronotropic effects. The pathways leading to adenosine formation have remained controversial.
Curto, Maria de Los Angeles +3 more
core +1 more source