Results 71 to 80 of about 1,475 (143)

Efficacy and Safety of 60 W Versus 90 W, 4‐s Radiofrequency Applications to the Esophagus‐Adjacent Left Atrial Posterior Wall During Pulmonary Vein Isolation: A Pilot Study

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
In this randomized pilot study, 60 W and 90 W QMODE+ RF applications for the periesophageal region achieved comparable acute block and low esophageal injury rates (4.2% each), with similar 1‐year arrhythmia‐free survival, although contact force was higher in the 60 W group.
Hideharu Okamatsu, Ken Okumura, Kakeru Tomaru, Junya Matsura, Kodai Negishi, Takuo Tsurugi, Yasuaki Tanaka, Masayoshi Uehara, Junjiro Koyama, Hirofumi Tomita   +9 more
wiley   +1 more source

Mapping DNA methylation to cardiac pathologies induced by beta-adrenergic stimulation in a large panel of mice

Epigenetics
Heart failure (HF) is a major global health challenge, contributing to over 18 million deaths annually. While the roles of genetic and environmental factors are widely studied, the role of DNA methylation in HF pathogenesis is not fully understood.
Caitlin Lahue, Eleanor Wong, Aryan Dalal, Wilson Tan Lek Wen, Shuxun Ren, Roger Foo, Yibin Wang, Christoph D. Rau   +7 more
doaj   +1 more source

Do Stimulants Promote Arrhythmic Risk: Insights From a Human‐Induced Pluripotent Stem Cell‐Derived Cardiomyocyte Model

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
At clinically relevant plasma concentrations, stimulant medications produced minimal effects on conduction velocity but modulated automaticity and repolarization in a hiPSC‐derived cardiomyocyte (hiPSC‐CM) model. These findings provide a foundation for future investigations of stimulant‐associated cardiac safety and support the utility of hiPSC‐CM ...
Alia Arslanova, Samantha Wong, Sonia Franciosi, Glen F. Tibbits, Maksymilian Prondzynski, Shubhayan Sanatani   +5 more
wiley   +1 more source

Senescence-like Phenotype After Chronic Exposure to Isoproterenol in Primary Quiescent Immune Cells

Biomolecules
Chronic stress is associated with a higher risk for carcinogenesis as well as age-related diseases and immune dysfunction. There is evidence showing that psychological stress can contribute to premature immunosenescence.
Michael Laumann, Philipp Palombo, Judy Fieres, Mara Thomas, Gabriele Saretzki, Alexander Bürkle, Maria Moreno-Villanueva   +6 more
doaj   +1 more source

Stepwise Localization of Non‐Pulmonary‐Vein Ectopy Using Cycle‐Length‐Based Activation Map Separation and Local Electrogram Morphology on the Affera System

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
On the Affera system, a single voltage‐map dataset containing both sinus and ectopic beats, collected without rhythm‐specific settings, can be separated by cycle length (coupling interval) into SR and PAC activation maps. Stepwise filtering by activation threshold (voltage‐per‐second, excluding far‐field potentials) and close‐unipolar QS‐like ...
Suguru Nishiuchi, Shingo Yoshimura, Takehito Sasaki, Kohki Nakamura, Shigeto Naito   +4 more
wiley   +1 more source

Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine Model

World Journal of Traditional Chinese Medicine
Objective: This study aimed to validate the synergistic effects of Cinnamomum verum (C. verum) barks and stingless bee honey (SBH) against cardiac hypertrophy (CH). Materials and Methods: Isoproterenol (ISO-group II-30 mg/kg)-induced cardiac hypertrophic
Arul Mozhi Padmanabhan, Victor Arokia Doss   +1 more
doaj   +1 more source

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

ATP Release and Purinergic Signaling Potentiate β‐Adrenergic Effects on Brown Adipocytes

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Marco Tozzi, Emilie B. Berggreen, Rui Zhang, Anders Gudiksen, Wei Li, Mathias B. Matz, Henriette Pilegaard, Jacob B. Hansen, Ivana Novak   +8 more
wiley   +1 more source

Na+,-K+-ATPase Deficiency Exacerbates Cardiac Fibrosis via Promoting ERRα-Mediated Myocardial Cell Injury and Macrophage Activation Under Isoproterenol-Challenged Conditions

Frontiers in Bioscience-Landmark
Background: Inflammation plays a pivotal role in the progression of tissue fibrosis. Our previous research demonstrated that Na+, K+-ATPase (NKA) α1 deficiency impairs mitochondrial function and accelerates isoproterenol (ISO)-induced ...
Ting Lei, Tao Liu, Yutong Liu, Yingnan Zhai, Ruijia Wang, Xiaoyi Tan, Hongli Liu, Xiaofei Yan   +7 more
doaj   +1 more source

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source