Results 61 to 70 of about 56,494 (249)

Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System

Advanced Electronic Materials, EarlyView.
This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella, Katelyn Neuman, Nolan Burson, Abigail N. Koppes, Ryan A. Koppes   +4 more
wiley   +1 more source

Nano‐Gs‐Protein Peptidomimetika: Rationales Design von Peptiden, die vom C‐Terminus von Gα abgeleitet sind und Schlüsselkomponenten der Gs‐β2AR‐Wechselwirkungen nachahmen

Angewandte Chemie, EarlyView.
G Protein‐gekoppelte Rezeptoren (GPCRs) sind wichtige therapeutische Zielstrukturen. Die Modulation der GPCR‐Aktivität über intrazelluläre Bindungsstellen gewinnt zunehmend an Bedeutung. Ein strukturell und computergestützter Ansatz ermöglichte die Entwicklung kleiner, vom G Protein abgeleiteter Peptidomimetika, die gezielt an die intrazelluläre ...
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

Effect of exogenous adiponectin on myocardial fibrosis in mice models with myocardial fibrosis

Cardiology Plus, 2016
Background: Myocardial fibrosis is closely associated with cardiac dysfunction, arrhythmia, and sudden cardiac death. A model of myocardial fibrosis induced by isoprenaline was used to determine the influence of exogenous adiponectin on myocardial ...
Feng-Lin Jin, Qiang Xiao, Ke-Yang Ding, Jian Hou, Su-Mei Li, Xiu-Chang Li   +5 more
doaj   +1 more source

Ventricular Action Potential Adaptation to Regular Exercise: Role of β-adrenergic and K\u3csub\u3eATP\u3c/sub\u3e Channel Function [PDF]

, 2017
Regular exercise training is known to affect the action potential duration (APD) and improve heart function, but involvement of β-adrenergic receptor (β-AR) subtypes and/or the ATP-sensitive K+ (KATP) channel is unknown.
Fitts, Robert H., Wang, Xinrui
core   +1 more source

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

Angewandte Chemie International Edition, EarlyView.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

Uso de dobutamina para la inducción de arritmias durante estimulación eléctrica programada del corazón Dobutamine use for arrythmia induction during electrical programmed heart stimulation

Revista Colombiana de Cardiología, 2006
Introducción: el isoproterenol es el fármaco que se ha empleado tradicionalmente para incrementar la inducción de arritmias cuando durante la estimulación eléctrica programada del corazón en condiciones basales, no se logra su inducción. La dobutamina es
Diego I Vanegas, Climaco de J Pérez, Juan de J Montenegro, Alejandro Orjuela   +3 more
doaj  

Caracterização funcional da hipertrofia miocárdica induzida pelo isoproterenol e de sua regressão

Arquivos Brasileiros de Cardiologia, 2001
OBJETIVO: Analisar as disfunções da hipertrofia miocárdica induzida pelo isoproterenol e de sua regressão. Corações isolados hipertrofiados por isoproterenol (ISO) (8 dias) e após 22 dias de sua suspensão (regressão) foram distendidos.
Neif Murad, Marcelo Fabiano de Franco, Paulo J. F. Tucci   +2 more
doaj   +1 more source

Growth Hormone Promotes Lipolysis and Impairs Insulin Sensitivity by Activating the ERK/HSL Signaling Pathway in Bovine Adipocytes

Animal Research and One Health, EarlyView.
This study was to evaluate the role of GH in lipolysis and insulin sensitivity in bovine adipocytes and clarify the underlying mechanism. Our findings demonstrate that GH activates ERK/HSL signaling pathway, promotes lipolysis, and impairs insulin sensitivity in bovine adipocytes.
Xinxing Gao, Hao Yu, Erminio Trevisi, Cai Lin, Zhiyuan Fang, Xinwei Li, Yuxiang Song, Wenwen Gao, Lin Lei, Xiliang Du, Guowen Liu   +10 more
wiley   +1 more source

Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background PDE2 (phosphodiesterase 2) is upregulated in human heart failure. Cardiac PDE2‐transgenic mice are protected against contractile dysfunction and arrhythmias in heart failure but whether an acute elevation of PDE2 could be of therapeutic value ...
Rima Kamel, Aurélia Bourcier, Jean Piero Margaria, Valentin Jin, Audrey Varin, Agnès Hivonnait, Françoise Mercier‐Nomé, Delphine Mika, Alessandra Ghigo, Flavien Charpentier, Vincent Algalarrondo, Emilio Hirsch, Rodolphe Fischmeister, Grégoire Vandecasteele, Jérôme Leroy   +14 more
doaj   +1 more source

Protective Effects of Achillea millefolium Extract on Myocardial Infarction Induced by Isoproterenol in Rats

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: In recent years, natural products have been widely used in traditional medicine to treat cardiovascular diseases. The aim of this study was to determine the cardioprotective effect of Achillea millefolium extract against ...
Somayeh Najafi Chaleshtori, Meisam Rahmani Khajoee, Zahra Lorigooini, Maryam Anjomshoa, Fariba Houshmand   +4 more
doaj