Results 51 to 60 of about 29,381 (199)

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Time-dependent responses of rat troponin I and cardiac injury following isoproterenol administration [PDF]

Medicinski Glasnik, 2011
Aim To develop a rat model of myocardial infarction induced by isoproterenol (ISO). We investigated a type of histological myocardial changes and cardiac troponin I (TnI) kinetic. Methods The study has used adult, male, Wistar strain rats.
Sabaheta Hasić, Radivoj Jadrić, Emina Kiseljaković, Amina Valjevac, Zakira Mornjaković, Mira Winterhalter-Jadrić   +5 more
doaj  

Tunnelling Nanotube‐Mediated Lysosome Sharing Promotes Osteocyte Survival via Transcellular Autophagy

Cell Proliferation, EarlyView.
This study provides the first definitive identification of tunnelling nanotubes (TNTs) between cultured osteocytes and shows TNT‐mediated lysosome transfer from healthy to stressed cells, restoring autophagic flux and preventing apoptosis. This discovery of transcellular autophagy reveals a new survival mechanism in osteocytes, offering potential ...
Jinbiao Qiang, Ronghao Jin, Tong Sha, Fang Zheng, Yijun Zhou, Yue Hu, Shuyu Zhang, Zhenming Yang, Mengdong Nie, Huanyu Luo, Xiaoduo Tang, Hao Guo, Zunxuan Xie, Jinwei Li, Hongchen Sun, Cangwei Liu, Ce Shi   +16 more
wiley   +1 more source

Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis

Frontiers in Pharmacology
Introduction: Isoproterenol (ISO) is regarded as an adrenergic non-selective β agonist. It regulates myocardial contractility and may cause damage to cardiac tissues.
Nuha Anajirih, Ahmed Abdeen, Ehab S. Taher, Afaf Abdelkader, Hoda A. Abd-Ellatieff, Mahmoud S. Gewaily, Nashwa E. Ahmed, Rasha H. Al-Serwi, Safwa M. Sorour, Heba M. Abdelkareem, Heba M. Abdelkareem, Elturabi Ebrahim, Mohamed El-Sherbiny, Florin Imbrea, Ilinca Imbrea, Mahmoud M. Ramadan, Mahmoud M. Ramadan, Ola A. Habotta   +17 more
doaj   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the cardioprotective potential of betulin in isoproterenol (ISO)-induced myocardial injury in rats. Methods: Wistar rats were divided into five groups (n=10): normal, ISO, nebivolol 5 mg/kg, and betulin (20 & 40 mg/kg ...
Hital Shah, Tejal Gandhi
doaj   +1 more source

Intravenous delivery of a microRNA-1 agomir improves isoproterenol-induced heart failure in mice

Di-san junyi daxue xuebao, 2019
Objective To investigate the therapeutic effect of intravenous administration of a microRNA-1 (miR-1) agomir on isoproterenol (ISO)-induced heart failure (HF) in mice. Methods Mouse models of HF were established by intraperitoneal injection of ISO for 28
HE Rui, DING Chang, HE Li
doaj   +1 more source

Prospective Trial of Radiofrequency Catheter Ablation of High Dominant Frequencies After Pulmonary Vein Isolation in Non‐Paroxysmal Atrial Fibrillation (PAD‐AF Trial): A Multicenter, Randomized Clinical Trial

Journal of Cardiovascular Electrophysiology, EarlyView.
In persistent AF, adjunctive dominant frequency‐guided ablation after pulmonary vein isolation did not significantly improve outcomes. Limited overlap between high‐frequency sites and low‐voltage areas suggests functional–structural dissociation, while right atrial low‐voltage burden predicts recurrence.
Koji Kumagai, Tomoaki Hasegawa, Daisuke Kutsuzawa, Yuichi Hanaki, Masahide Harada, Hitoshi Hachiya, Yuhi Hasebe, Kazuki Noda, Minoru Yambe, Hirohito Metoki, Kazutaka Aonuma   +10 more
wiley   +1 more source

Late‐Onset Suspected Coronary Vasospasm Following Focal Monopolar Pulsed‐Field Ablation for Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Coronary vasospasm is a recognized complication of pulsed‐field ablation (PFA), but delayed events are rarely described. Methods and Results A 64‐year‐old man underwent atrial fibrillation ablation using a focal monopolar PFA catheter.
Yui Araki, Kanae Hasegawa, Ryohei Nomura, Hiroshi Tada   +3 more
wiley   +1 more source

Comparison of Spatio‐Temporal Dispersion Electrogram Ablation and Low Voltage Zone Ablation in Patients With Persistent Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, EarlyView.
This study compared STDE‐guided versus LVZ‐guided ablation beyond PVI in 107 persistent AF patients. At 24 months, the AF‐free survival rate was significantly higher in the STDE group (76.3% vs. 58.4%, p=0.027). STDE ablation independently reduced recurrence risk (HR: 0.29, p=0.004), providing superior clinical efficacy over LVZ ablation.
Yutaro Kaneko, Yoshihisa Naruse, Yuki Tokonami, Kazuki Ito, Taro Narumi, Makoto Sano, Yuichiro Maekawa   +6 more
wiley   +1 more source