Results 21 to 30 of about 56,118 (235)
Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction.
PLoS ONE, 2020 Sex-related differences in cardiovascular diseases are highly complex in humans and model-dependent in experimental laboratory animals. The objective of this work was to comprehensively investigate key sex differences in the response to acute and ...
Marianne K O Grant +4 more
doaj +1 more source
Cardioprotective effect of Ginger in a rat model of myocardial damage and its possible intervention in PERK-ATF4-CHOP-PUMA apoptotic pathway [PDF]
The Ukrainian Biochemical Journal, 2023 For today the exact mechanisms of myocardial infarction and ischemia/reperfusion injury are still not fully understood. ER stress and integrated stress response pathways are thought to play an essential role in myocardial damage. This includes activation
M. M. Mohammed +3 more
doaj +1 more source
Upstream CB1R Regulation of β-Adrenergic Memory Consolidation. [PDF]
HippocampusABSTRACT Object recognition memory (ORM) plays a key role in identifying familiar items and encoding episodic information. ORM consolidation depends on β‐adrenergic receptor (βAR) signaling and is associated with increased BDNF expression in the dorsal hippocampus.
Rossato JI +9 more
europepmc +2 more sources
Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. [PDF]
, 2018 Modification of membrane receptor makeup is one of the most efficient ways to control input-output signals but is usually achieved by expressing DNA or RNA-encoded proteins or by using other genome-editing methods, which can be technically challenging ...
Baikoghli, Mo +7 more
core +2 more sources
Journal of Medicine in Scientific Research, 2018 Aim and Background Congenital heart diseases constitute a major category of disorders associated with pulmonary hypertension in atrial septal defect there is tendency to repair essentially all large defect except some of those with severe obstructive ...
Amir S Michael
doaj +1 more source
Frontiers in Physiology, 2020 Neuronal function and their survival depend on the activation of ion channels. Loss of ion channel function is known to induce neurodegenerative diseases such as Parkinson’s that exhibit loss of dopaminergic neurons; however, mechanisms that could limit ...
Yuyang Sun +5 more
doaj +1 more source
Life, 2022 This study aimed to evaluate the cardioprotective effects of L-2-oxothiazolidine-4-carboxylate (OTC) against isoproterenol (ISO)-induced acute myocardial infarction (MI) in rats.
Marija Angelovski +6 more
doaj +1 more source
Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of G(i)- and G(q)-mediated signaling [PDF]
, 1999 RGS proteins (Regulators of G protein Signaling) are a recently discovered family of proteins that accelerate the GTPase activity of heterotrimeric G protein α subunits of the i, q, and 12 classes.
Backlund, Peter S. +5 more
core +1 more source
Current Issues in Molecular Biology, 2022 Dry mouth is characterized by lower saliva production and changes in saliva composition. In patients with some salivary gland function remaining, pharmaceutical treatments are not recommended; therefore, new, more effective methods of promoting saliva ...
Samar A. Alghamdi +8 more
doaj +1 more source
Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic [PDF]
, 2006 Endothelin-1 (ET-1) is elevated in patients with atrial fibrillation (AF) and heart failure. We investigated effects of ET-1 on human atrial cellular electrophysiological measurements expected to influence the genesis and maintenance of AF.
Kane, K.A. +3 more
core +1 more source