Results 91 to 100 of about 80,153 (209)

Isoquinoline Alkaloids and Basis of Therapeutic Action

, 2010
After fifty years of DNA targeting through intercalators and groove binders and related studies now the current focus is in RNA targeting. Polyadenylic acid [poly(A)] tail of mRNA has been recently established as a potential drug target due to its ...
Giri, Prabal, Kumar, G Suresh
core  

Nanoparticle formation of an antimicrobial peptide induced by sulfated β-cyclodextrin: Application to alkaloid encapsulation

Carbohydrate Polymer Technologies and Applications
The association of polyanionic β-cyclodextrin (βCD) derivatives with the nonaggregating polycationic antimicrobial peptide Dhvar4 was studied in water at 296 K without a buffer to explore their potential for forming nanoparticles capable of encapsulating
Zsombor Miskolczy, Mónika Megyesi, Beáta Mándityné Huszka, István Mándity, László Biczók   +4 more
doaj   +1 more source

Asymmetric Electrophilic alpha-Amidoalkylation 6 [PDF]

, 1989
Praschak, Ilona, Wanner, Klaus Th.
core   +1 more source

Isoquinoline-Based Biaryls as a Robust Scaffold for Microtubule Inhibitors

, 2019
We here report the discovery of isoquinoline-based biaryls as a new scaffold for colchicine domain tubulin inhibitors. Colchicine domain inhibitors comprise a structurally diverse class of compounds offering highly desirable cytotoxic and vascular ...
Carina Glas (7138379), Julia Ahlfeld (7071521), Oliver Thorn-Seshold (7049363), Benedikt Melzer (7138380), Franz Bracher (7138392), Constanze Heise (7138386), Monique Preusse (7138389), Yvonne Kraus (7071371), Li Gao (7138381)   +8 more
core   +1 more source

CHEMICAL STUDIES ON THE MINOR ISOQUINOLINE ALKALOIDS FROM CORYDALIS-SOLIDA SUBSP BRACHYLOBA

, 1991
Continuing our studies on Corydalis species growing in Turkey, from which isoquinoline alkaloids have been isolated, we have investigated another species, Corydalis solida subsp. brachyloba (Papaveraceae, Fumarioideae). As a result (+)-fumarophycine (1),
TEMIZER, H, SENER, B
core   +1 more source

Ultra-performance liquid chromatography coupled with mass spectrometry profiling and evaluation of in vitro anti-Plasmodium falciparum activity of extracts from a Congolese Ancistrocladus species

Discover Chemistry
Malaria remains one of the leading causes of death globally, particularly in developing countries. This study aimed to investigate the antimalarial activity and UPLC-MS profiling of crude extracts from a new Ancistrocladus species collected in Banalia ...
Justin Bazibuhe Safari, Félicien Mushagalusa Kasali, Séverin Muyisa Kavatsurwa   +2 more
doaj   +1 more source

The Elevation of LC-ESI-Q-TOF-MS Response in the Analysis of Isoquinoline Alkaloids from Some Papaveraceae and Berberidaceae Representatives

Journal of Analytical Methods in Chemistry, 2017
Twenty-five methanol extracts obtained from various representatives of Papaveraceae and Berberidaceae botanical families (genera: Papaver, Argemone, Eschscholzia, Chelidonium, Glaucium, and Berberis) were screened for their alkaloid content in an ...
Wirginia Kukula-Koch
doaj   +1 more source

Enantioselective synthesis of isoquinoline alkaloids: phenylethylisoquinoline and aporphine alkaloids

, 1987
A new and improved procedure for the preparation of (R)-2-alkoxycarbonyl-1-formyl-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolines has been developed beginning from D-(−)-tartaric acid.
Zbigniew Czarnocki, Walter A. Szarek, David B. MacLean   +2 more
core   +1 more source

Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper. [PDF]

Molecules, 2022
Parvin MS, Chlebek J, Hošťálková A, Catapano MC, Lomozová Z, Macáková K, Mladěnka P.   +6 more
europepmc   +1 more source

Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase. [PDF]

Curr Issues Mol Biol, 2022
Kim JH, Kim JH, Cho CW, Hur M, Park WT, Moon YH, Koo SC, Hur YC, Kang JS, Lee IS.   +9 more
europepmc   +1 more source