Results 41 to 50 of about 11,247 (220)

Atividade leishmanicida e citotoxicidade de constituintes químicos de duas espécies de Annonaceae cultivadas no nordeste do Brasil [PDF]

, 2011
INTRODUCTION: Visceral leishmaniasis is endemic in 88 countries, with a total of 12 million people infected and 350 million at risk. In the search for new leishmanicidal agents, alkaloids and acetogenins isolated from leaves of Annona squamosa and seeds ...
ANDRADE JÚNIOR, Heitor Franco de, BEVILÁQUA, Cláudia Maria Leal, BRASIL, Nilce Viana Gramosa Pompeu de Sousa, COSTA, Igor Rafael Sousa, FALCÃO, Maria José Cajazeiras, MACHADO, Lyeghyna Karla Andrade, MORAIS, Selen Maia de, VILA-NOVA, Nadja Soares   +7 more
core   +2 more sources

Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome

Cell Proliferation, EarlyView.
In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge, Chenxiang Zhang, Yilong Zhao, Haiyang Zhao, Shuai Zhu, Tao Tang, Guorui Zhang, Qiang Wang, Hui Wang   +8 more
wiley   +1 more source

Unveiling the impact of nitrogen deficiency on alkaloid synthesis in konjac corms (Amorphophallus muelleri Blume)

BMC Plant Biology
Background Konjac corms are known for their alkaloid content, which possesses pharmacological properties. In the primary cultivation areas of konjac, nitrogen deficiency is a common problem that significantly influences alkaloid synthesis.
Ying Qi, Penghua Gao, Shaowu Yang, Lifang Li, Yanguo Ke, Yongteng Zhao, Feiyan Huang, Lei Yu   +7 more
doaj   +1 more source

Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance

New Phytologist, EarlyView.
Summarised methodology for metabolite biomarker discovery and genomic targets selection for those metabolites to predict high‐throughput phenotypic and agronomic traits of interest for direct uptake in breeding programmes. Summary Global warming is driving climate change to levels not experienced since the advent of agriculture, primarily due to ...
Agyeya Pratap, Arash Fazeli, Ali Bandehagh, Nicolas L. Taylor   +3 more
wiley   +1 more source

The alkaloids of Corydalis hendersonii Hemsl. contribute to the cardioprotective effect against ischemic injury in mice by attenuating cardiomyocyte apoptosis via p38 MAPK signaling pathway

Chinese Medicine, 2023
Highlights The total extract of Corydalis hendersonii Hemsl. (CH) and the rich alkaloids fraction (RAF) of CH showed significant cardioprotective effect on mice following acute myocardial infarction.
Fuxing Ge, Xiaoli Gao, Xiaochun Zhou, Junjun Li, Xiaojing Ma, Meiwen Huang, Sana Wuken, Pengfei Tu, Chao An, Xingyun Chai   +9 more
doaj   +1 more source

Synthesis and reactions of 1-amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones [PDF]

, 2008
1-Amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones, as previously unknown ring-annelated isoquinolines with a 3-aminoimidazolidin-4-one scaffold, were selectively prepared upon reacting 2-carbamoylmethyl- or 2-ethoxycarbonylmethyl-3,4 ...
De Kimpe, Norbert, Holzer, Wolfgang, Mangelinckx, Sven, Martynaitis, Vytas, Solovjova, Joana, Šačkus, Algirdas   +5 more
core   +2 more sources

Poplar miR1447 Is a Negative Regulator of Disease Resistance Through the SA‐Dependent Pathway

Plant Biotechnology Journal, EarlyView.
ABSTRACT Although microRNA1447 (miR1447) regulates poplar responses to abiotic stress and pest infestation, how miR1447 regulates poplar immunity against pathogens and its underlying molecular mechanisms remain to be elucidated. Here, we revealed that miR1447 functioned as a negative regulator of poplar disease resistance against fungal and bacterial ...
Dandan Xiao, Kaijing Rong, Tiantian Fu, Yicheng Li, Chun Wang, Ke Zhou, Ruen Yu, Xiaoqian Yang, Yuzhang Yang, Yuanyuan Wang, Yanwei Wang, Yonglin Wang   +11 more
wiley   +1 more source

Research Progress on Natural Benzophenanthridine Alkaloids and their Pharmacological Functions: A Review

Natural Product Communications, 2016
Benzophenanthridine alkaloids belong to the benzyl isoquinoline family of alkaloids, which are mainly found in Papaveraceae and Rutaceae. To date, over 100 compounds have been isolated from natural herbal medicines which display a variety of ...
Na Han, Zhiyou Yang, Zhihui Liu, Huijing Liu, Jun Yin   +4 more
doaj   +1 more source

Transcriptional Regulation of the Novel Theacrine Synthase Gene CsTcS2 by the CsTINY–CsWRKY33 Module Underpins Theacrine Biosynthesis in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu, Lihua Zhu, Chenyu Shao, Siyi Xie, Na Li, Xinyu Li, Fang Wang, Lvwen Peng, Huiying Jin, Fanghuizi Shang, Jianan Huang, Zhonghua Liu, Na Tian, Shuoqian Liu   +13 more
wiley   +1 more source

PREPARATIVE SEPARATION OF ISOQUINOLINE ALKALOIDS FROM PHELLODENDRI CORTEX BY PH-ZONE-REFINING COUNTER-CURRENT CHROMATOGRAPHY

Química Nova
pH-Zone-refining counter-current chromatography (PZRCCC) was successfully used for preparative separation isoquinoline alkaloids from Phellodendri Cortex.
Daijie Wang, Shanming Tian, Li Cui, Huijiao Yan, Xiangyun Song, Yuguo Liu, Fei Xu, Junjian Ma   +7 more
doaj   +1 more source