Results 51 to 60 of about 80,153 (209)

AKR1C3 Inhibitory Potency of Naturally-occurring Amaryllidaceae Alkaloids of Different Structural Types

Natural Product Communications, 2017
Aldo-keto reductase 1C3 (AKR1C3) is an important human enzyme that participates in the reduction of steroids and prostaglandins, which leads to proliferative signaling.
Daniela Hulcová, Kateřina Breiterová, Lucie Zemanová, Tomáš Siatka, Marcela Šafratová, Nina Vaněčková, Anna Hošťálková, Vladimír Wsól, Lucie Cahlíková   +8 more
doaj   +1 more source

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic, Jovana Rajkovic, Radmila Novakovic, Javad Sharifi‐Rad, Daniela Calina   +4 more
wiley   +1 more source

Natural Alkaloids as Antimicrobial Agents: Mechanisms, Potentials and Challenges

Molecules
Antimicrobial resistance (AMR) poses a significant global health threat, with multidrug-resistant pathogens undermining the effectiveness of conventional antibiotics. Natural alkaloids, a diverse group of nitrogen-containing compounds mainly derived from
Xi-Zhong Zhang, Ming-Xia Chen, Rui Hou, Wan-Qin Wang, Zhen-Dan He, Jie-Shu You, Xun Song   +6 more
doaj   +1 more source

Host-Guest Chemistry of Alkaloids

Natural Product Communications, 2012
Binding of alkaloids by different hosts (native and modified cyclodextrins, cucurbiturils, calixarenes, and metal complexes of porphyrin and Salphen-type ligands), as well as receptor properties of alkaloid based hosts are reviewed.
Anatoly K. Yatsimirsky
doaj   +1 more source

Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis

Molecules, 2009
The stem bark of Phoebe grandis afforded one new oxoproaporphine; (–)-grandine A (1), along with six known isoquinoline alkaloids: (–)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that
Khalijah Awang, Marc Litaudon, Noel F. Thomas, A. Hamid A. Hadi, Ahmad Nazif Aziz, Mat Ropi Mukhtar   +5 more
doaj   +1 more source

Phytochemical Profiling and Evaluation of Antibacterial, Anticancer, Anti‐inflammatory, and Wound‐Healing Activities of Endophytic Fungi Isolated From Atalantia racemosa

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
ABSTRACT Endophytic fungi are recognized as prolific sources of structurally diverse secondary metabolites with significant pharmaceutical potential. In the present study, endophytic fungi were isolated from healthy tissues of Atalantia racemosa (Rutaceae), an ethnomedicinal plant traditionally used for respiratory disorders and blood purification.
Sushma M, Arun Shettar, Joy Hoskeri, Vedamurthy A B   +3 more
wiley   +1 more source

Monoaminergic, Ion Channel and Enzyme Inhibitory Activities of Natural Aporphines, their Analogues and Derivatives

Natural Product Communications, 2008
The aporphine alkaloids constitute the second-largest group of isoquinoline alkaloids. Nevertheless, only a relatively small number of natural aporphines and their derivatives have been studied from a pharmacological viewpoint.
Bruce K. Cassels, Marcelo Asencio
doaj   +1 more source

Synthesis and Antifungal Evaluation of Isoquinoline‐3‐amide Derivatives Containing a Phenoxypyridine Moiety for Plant Protection

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The splicing of phenoxypyridine moieties to isoquinolin‐3‐carboxylic acid enhanced its biological activity against plant pathogenic fungi. Among target compounds, compound X6 demonstrated significant antifungal activity against Botrytis cinerea in vitro and in vivo assays, Molecular docking, molecular dynamics simulations, as well as SDH enzyme assay ...
Jiayao Zhang, Shuaipeng Sun, Yajing Guo, Zhiyuan Xu, Jing Zhang, Gang Feng, Haixin Ding, Qiang Xiao   +7 more
wiley   +1 more source

Synthesis of Trisubstituted Isoquinoline Alkaloids

, 2019
Isoquinoline alkaloids encompasses a large and important group of naturally occurring substances that exhibit a diverse array of biological activity, including treating Yaws and worm infections,1 as well as showing activity as both topoisomerase ...
Tran, Thao, Cartwight, Kaitie C., Anderson, Carolyn E., Farrell, Zach   +3 more
core   +1 more source

Flavasperfurans A and B, Two New Asperfuran Derivatives From the Marine‐Derived Fungus Aspergillus flavus

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Two new asperfurans (1 and 2) and 23 known compounds from marine Aspergillus flavus were characterized by NMR, HRESIMS, DP4+, and ECD. Asperfuran (3) potently inhibited RSL3‐induced ferroptosis (EC50 = 0.81 µM). ABSTRACT Marine microorganisms represent a prolific reservoir of chemically diverse natural products endowed with considerable therapeutic ...
Chun‐Xiu Wang, Zheng‐Biao Zou, Li‐Sheng Li, Cheng‐Hai Gao, Xian‐Wen Yang   +4 more
wiley   +1 more source